Multidisciplinary treatment approach in treacher collins syndrome

Joseph B. Hylton, Vladimir Leon-Salazar, Gary C Anderson, Nanci L O De Felippe

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Treacher Collins syndrome (TCS) is a common genetic disorder with high penetrance and phenotypic variability. First and second branchial arches are affected in TCS, resulting in craniofacial and intraoral anomalies such as: severe convex facial profile; midface hypoplasia; microtia; eyelid colobomas; mandibular retrognathism; cleft palate; dental hypoplasia; heterotopic teeth; maxillary transverse hypoplasia; anterior open bite; and Angle Class II molar relationship. A high incidence of caries is also a typical finding in TCS patients. Nonetheless, even simple dental restorative procedures can be challenging in this patient population due to other associated medical conditions, such as: congenital heart defects; decreased oropharyngeal airways; hearing loss; and anxiety toward treatment. These patients often require a multidisciplinary treatment approach, including: audiology; speech and language pathology; otorhinolaryngology; general dentistry; orthodontics; oral and maxillofacial surgery; and plastic and reconstructive surgeries to improve facial appearance. This paper's purpose was to present a current understanding of Treacher Collins syndrome etiology, phenotype, and current treatment approaches.

Original languageEnglish (US)
Pages (from-to)15-21
Number of pages7
JournalJournal of Dentistry for Children
Issue number1
StatePublished - Jan 1 2012


  • Dental treatment
  • Malocclusion
  • Treacher collins syndrome


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