TY - JOUR
T1 - Multidisciplinary treatment approach in treacher collins syndrome
AU - Hylton, Joseph B.
AU - Leon-Salazar, Vladimir
AU - Anderson, Gary C
AU - De Felippe, Nanci L O
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Treacher Collins syndrome (TCS) is a common genetic disorder with high penetrance and phenotypic variability. First and second branchial arches are affected in TCS, resulting in craniofacial and intraoral anomalies such as: severe convex facial profile; midface hypoplasia; microtia; eyelid colobomas; mandibular retrognathism; cleft palate; dental hypoplasia; heterotopic teeth; maxillary transverse hypoplasia; anterior open bite; and Angle Class II molar relationship. A high incidence of caries is also a typical finding in TCS patients. Nonetheless, even simple dental restorative procedures can be challenging in this patient population due to other associated medical conditions, such as: congenital heart defects; decreased oropharyngeal airways; hearing loss; and anxiety toward treatment. These patients often require a multidisciplinary treatment approach, including: audiology; speech and language pathology; otorhinolaryngology; general dentistry; orthodontics; oral and maxillofacial surgery; and plastic and reconstructive surgeries to improve facial appearance. This paper's purpose was to present a current understanding of Treacher Collins syndrome etiology, phenotype, and current treatment approaches.
AB - Treacher Collins syndrome (TCS) is a common genetic disorder with high penetrance and phenotypic variability. First and second branchial arches are affected in TCS, resulting in craniofacial and intraoral anomalies such as: severe convex facial profile; midface hypoplasia; microtia; eyelid colobomas; mandibular retrognathism; cleft palate; dental hypoplasia; heterotopic teeth; maxillary transverse hypoplasia; anterior open bite; and Angle Class II molar relationship. A high incidence of caries is also a typical finding in TCS patients. Nonetheless, even simple dental restorative procedures can be challenging in this patient population due to other associated medical conditions, such as: congenital heart defects; decreased oropharyngeal airways; hearing loss; and anxiety toward treatment. These patients often require a multidisciplinary treatment approach, including: audiology; speech and language pathology; otorhinolaryngology; general dentistry; orthodontics; oral and maxillofacial surgery; and plastic and reconstructive surgeries to improve facial appearance. This paper's purpose was to present a current understanding of Treacher Collins syndrome etiology, phenotype, and current treatment approaches.
KW - Dental treatment
KW - Malocclusion
KW - Treacher collins syndrome
UR - http://www.scopus.com/inward/record.url?scp=84861034405&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861034405&partnerID=8YFLogxK
M3 - Review article
C2 - 22449504
AN - SCOPUS:84861034405
SN - 1551-8949
VL - 79
SP - 15
EP - 21
JO - Journal of Dentistry for Children
JF - Journal of Dentistry for Children
IS - 1
ER -