Multicompartment micelles from pH-responsive miktoarm star block terpolymers

Chun Liu; Marc A. Hillmyer; Timothy P. Lodge

doi:10.1021/la900845u

Multicompartment micelles from pH-responsive miktoarm star block terpolymers

Chun Liu, Marc A. Hillmyer, Timothy P. Lodge

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

We describe the synthesis of pH-responsive miktoarm star block terpolymers ,μ-[polystyrene][poly(ethylene oxide)] [poly(2-(dimethylamino)ethyl acrylate)] (μ-SODA) using a combination of two successive living anionic polymerizations and one reversible addition-fragmentation chain-transfer polymerization. Poly[2-(dimethylamino)ethyl acrylate] (PDMAEA) is a weak polybase that is hydrophilic at low pH and hydrophobic at high pH because of the protonation of the dimethylamino functional group with decreasing pH. In addition, our results suggest that PDMAEA is immiscible with polystyrene (PS), a feature that is desirable for the formation of multicompartment micelles. Using a combination of dynamic light scattering and cryogenic transmission electron microscopy, we demonstrate that μ-SODA micelles formed in water evolve from mixed corona (PEO + PDMAEA corona; PS core) and predominantly spherical micelles to multicompartment (PEO corona; PS - PDMAEA core) micelles with increasing pH.

Original language	English (US)
Pages (from-to)	13718-13725
Number of pages	8
Journal	Langmuir
Volume	25
Issue number	24
DOIs	https://doi.org/10.1021/la900845u
State	Published - Dec 15 2009

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title = "Multicompartment micelles from pH-responsive miktoarm star block terpolymers",

abstract = "We describe the synthesis of pH-responsive miktoarm star block terpolymers ,μ-[polystyrene][poly(ethylene oxide)] [poly(2-(dimethylamino)ethyl acrylate)] (μ-SODA) using a combination of two successive living anionic polymerizations and one reversible addition-fragmentation chain-transfer polymerization. Poly[2-(dimethylamino)ethyl acrylate] (PDMAEA) is a weak polybase that is hydrophilic at low pH and hydrophobic at high pH because of the protonation of the dimethylamino functional group with decreasing pH. In addition, our results suggest that PDMAEA is immiscible with polystyrene (PS), a feature that is desirable for the formation of multicompartment micelles. Using a combination of dynamic light scattering and cryogenic transmission electron microscopy, we demonstrate that μ-SODA micelles formed in water evolve from mixed corona (PEO + PDMAEA corona; PS core) and predominantly spherical micelles to multicompartment (PEO corona; PS - PDMAEA core) micelles with increasing pH.",

author = "Chun Liu and Hillmyer, {Marc A.} and Lodge, {Timothy P.}",

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T1 - Multicompartment micelles from pH-responsive miktoarm star block terpolymers

AU - Liu, Chun

AU - Hillmyer, Marc A.

AU - Lodge, Timothy P.

PY - 2009/12/15

Y1 - 2009/12/15

N2 - We describe the synthesis of pH-responsive miktoarm star block terpolymers ,μ-[polystyrene][poly(ethylene oxide)] [poly(2-(dimethylamino)ethyl acrylate)] (μ-SODA) using a combination of two successive living anionic polymerizations and one reversible addition-fragmentation chain-transfer polymerization. Poly[2-(dimethylamino)ethyl acrylate] (PDMAEA) is a weak polybase that is hydrophilic at low pH and hydrophobic at high pH because of the protonation of the dimethylamino functional group with decreasing pH. In addition, our results suggest that PDMAEA is immiscible with polystyrene (PS), a feature that is desirable for the formation of multicompartment micelles. Using a combination of dynamic light scattering and cryogenic transmission electron microscopy, we demonstrate that μ-SODA micelles formed in water evolve from mixed corona (PEO + PDMAEA corona; PS core) and predominantly spherical micelles to multicompartment (PEO corona; PS - PDMAEA core) micelles with increasing pH.

AB - We describe the synthesis of pH-responsive miktoarm star block terpolymers ,μ-[polystyrene][poly(ethylene oxide)] [poly(2-(dimethylamino)ethyl acrylate)] (μ-SODA) using a combination of two successive living anionic polymerizations and one reversible addition-fragmentation chain-transfer polymerization. Poly[2-(dimethylamino)ethyl acrylate] (PDMAEA) is a weak polybase that is hydrophilic at low pH and hydrophobic at high pH because of the protonation of the dimethylamino functional group with decreasing pH. In addition, our results suggest that PDMAEA is immiscible with polystyrene (PS), a feature that is desirable for the formation of multicompartment micelles. Using a combination of dynamic light scattering and cryogenic transmission electron microscopy, we demonstrate that μ-SODA micelles formed in water evolve from mixed corona (PEO + PDMAEA corona; PS core) and predominantly spherical micelles to multicompartment (PEO corona; PS - PDMAEA core) micelles with increasing pH.

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Multicompartment micelles from pH-responsive miktoarm star block terpolymers

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