Multicentric tracking of multiple agents by anterior cingulate cortex during pursuit and evasion

Seng Bum Michael Yoo, Jiaxin Cindy Tu, Benjamin Yost Hayden

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Successful pursuit and evasion require rapid and precise coordination of navigation with adaptive motor control. We hypothesize that the dorsal anterior cingulate cortex (dACC), which communicates bidirectionally with both the hippocampal complex and premotor/motor areas, would serve a mapping role in this process. We recorded responses of dACC ensembles in two macaques performing a joystick-controlled continuous pursuit/evasion task. We find that dACC carries two sets of signals, (1) world-centric variables that together form a representation of the position and velocity of all relevant agents (self, prey, and predator) in the virtual world, and (2) avatar-centric variables, i.e. self-prey distance and angle. Both sets of variables are multiplexed within an overlapping set of neurons. Our results suggest that dACC may contribute to pursuit and evasion by computing and continuously updating a multicentric representation of the unfolding task state, and support the hypothesis that it plays a high-level abstract role in the control of behavior.

Original languageEnglish (US)
Article number1985
JournalNature communications
Volume12
Issue number1
DOIs
StatePublished - Mar 31 2021

Bibliographical note

Publisher Copyright:
© 2021, The Author(s).

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

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