Multicenter study of the safety and efficacy of a 585 nm pulsed-dye laser for the nonablative treatment of facial rhytides

T. S.Jeffrey Hsu, Brian Zelickson, Jeffrey S. Dover, Suzanne Kilmer, Jay Burns, George Hruza, Douglas B. Brown, Eric F. Bernstein

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

OBJECTIVE. The objective of this study was to assess the safety and efficacy of a 585 nm flashlamp pulsed-dye laser for the nonablative treatment of facial rhytides. METHODS. A multicenter prospective randomized controlled study on 58 volunteers was performed. A split-face approach was adopted, with one periorbital region acting as a control and the other receiving either one or two treatments. Patients were photographed and imaged three-dimensionally before and after treatment. Histologic sections were analyzed. RESULTS. Three-dimensional topographic evaluation showed improvements of 9.8% (p = .0022) and 15% (p = .0029) in surface roughness for single and double treatments, respectively. Histology revealed an increase in type I collagen messenger ribonucleic acid expression, type III procollagen, chondroitin sulfate, and grenz zone thickness. Two treatments resulted in greater improvement than one treatment. CONCLUSION. Clinical improvement was achieved following a single treatment. Further improvement was observed following a second treatment. The subjective evaluation of clinical improvement was consistent with both histologic and topographic quantitative measurements.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalDermatologic Surgery
Volume31
Issue number1
StatePublished - Jan 1 2005

Fingerprint Dive into the research topics of 'Multicenter study of the safety and efficacy of a 585 nm pulsed-dye laser for the nonablative treatment of facial rhytides'. Together they form a unique fingerprint.

  • Cite this

    Hsu, T. S. J., Zelickson, B., Dover, J. S., Kilmer, S., Burns, J., Hruza, G., Brown, D. B., & Bernstein, E. F. (2005). Multicenter study of the safety and efficacy of a 585 nm pulsed-dye laser for the nonablative treatment of facial rhytides. Dermatologic Surgery, 31(1), 1-9.