Multicenter comparison of once- and twice-daily isradipine to hydrochlorothiazide for the treatment of hypertension in elderly patients

Jordan L. Holtzman, Alan Abrams, Ralph Cutler, Bruce Hamilton, Walter M. Kirkendall, Gilbert Neri, G. H. Stein, Katherine P. Matthews

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

After 8 weeks of isradipine, a twice-a-day dihydropyridine calcium channel blocker, 49% of elderly patients showed a complete response (sitting diastolic blood presssure ≤85 mm Hg) and 36% showed a partial response (sitting diastolic blood pressure decrease ≥10 mm Hg) for an 85% total response rate. Hydrochlorothiazide gave a complete response in 36% of the patients and a partial response in 33%, for a 69% total response rate (p < 0.0046). Because elderly subjects have reduced clearance for many drugs, we determined how those who responded to twice-a-day administration would respond to once-a-day administration. After 4 weeks of isradipine administered once a day, 54% of the patients showed a complete or partial response, whereas 38% of the patients who were changed to placebo showed a response. In contrast, 82% of patients receiving hydrochlorothiazide once a day showed a response, whereas 60% of patients who were changed to placebo showed a response. these data indicate that the standard formulation of isradipine was not effective when administered once a day.

Original languageEnglish (US)
Pages (from-to)590-597
Number of pages8
JournalClinical pharmacology and therapeutics
Volume48
Issue number5
DOIs
StatePublished - Nov 1990

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