Multiband diffusion-weighted MRI of the eye and orbit free of geometric distortions using a RARE-EPI hybrid

Katharina Paul, Till Huelnhagen, Eva Oberacker, Daniel Wenz, André Kuehne, Helmar Waiczies, Sebastian Schmitter, Oliver Stachs, Thoralf Niendorf

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Diffusion-weighted imaging (DWI) provides information on tissue microstructure. Single-shot echo planar imaging (EPI) is the most common technique for DWI applications in the brain, but is prone to geometric distortions and signal voids. Rapid acquisition with relaxation enhancement [RARE, also known as fast spin echo (FSE)] imaging presents a valuable alternative to DWI with high anatomical accuracy. This work proposes a multi-shot diffusion-weighted RARE-EPI hybrid pulse sequence, combining the anatomical integrity of RARE with the imaging speed and radiofrequency (RF) power deposition advantage of EPI. The anatomical integrity of RARE-EPI was demonstrated and quantified by center of gravity analysis for both morphological images and diffusion-weighted acquisitions in phantom and in vivo experiments at 3.0 T and 7.0 T. The results indicate that half of the RARE echoes in the echo train can be replaced by EPI echoes whilst maintaining anatomical accuracy. The reduced RF power deposition of RARE-EPI enabled multiband RF pulses facilitating simultaneous multi-slice imaging. This study shows that diffusion-weighted RARE-EPI has the capability to acquire high fidelity, distortion-free images of the eye and the orbit. It is shown that RARE-EPI maintains the immunity to B0 inhomogeneities reported for RARE imaging. This benefit can be exploited for the assessment of ocular masses and pathological changes of the eye and the orbit.

Original languageEnglish (US)
Article numbere3872
JournalNMR in biomedicine
Issue number3
StatePublished - Mar 2018

Bibliographical note

Funding Information:
This work was funded in part (TN) by the Helmholtz Alliance ICEMED – Imaging and Curing Environmental Metabolic Diseases through the


  • applications
  • diffusion methods
  • diffusion weighted imaging
  • methods and engineering, diffusion MR sequences
  • methods and engineering, human study
  • neruological

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