Multi-receiver solid-state NMR using polarization optimized experiments (POE) at ultrafast magic angle spinning

T. Gopinath, Daniel K. Weber, Gianluigi Veglia

Research output: Contribution to journalArticle

Abstract

Ultrafast magic angle spinning (MAS) technology and 1H detection have dramatically enhanced the sensitivity of solid-state NMR (ssNMR) spectroscopy of biopolymers. We previously showed that, when combined with polarization optimized experiments (POE), these advancements enable the simultaneous acquisition of multi-dimensional 1H- or 13C-detected experiments using a single receiver. Here, we propose a new sub-class within the POE family, namely HC-DUMAS, HC-MEIOSIS, and HC-MAeSTOSO, that utilize dual receiver technology for the simultaneous detection of 1H and 13C nuclei. We also expand this approach to record 1H-, 13C-, and 15N-detected homonuclear 2D spectra simultaneously using three independent receivers. The combination of POE and multi-receiver technology will further shorten the total experimental time of ssNMR experiments for biological solids.

Original languageEnglish (US)
Pages (from-to)267-285
Number of pages19
JournalJournal of biomolecular NMR
Volume74
Issue number4-5
DOIs
StatePublished - May 1 2020

Keywords

  • HC-DUMAS
  • HC-MAeSTOSO
  • HC-MEIOSIS
  • Multi-acquisition
  • Multi-receiver
  • Polarization optimized experiments (POE)
  • SIM-CP
  • Solid-state NMR
  • Ultra-fast magic angle spinning

PubMed: MeSH publication types

  • Journal Article

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