Multi-omic atlas of the parahippocampal gyrus in Alzheimer’s disease

Claire Coleman, Minghui Wang, Erming Wang, Courtney Micallef, Zhiping Shao, James M. Vicari, Yuxin Li, Kaiwen Yu, Dongming Cai, Junmin Peng, Vahram Haroutunian, John F. Fullard, Jaroslav Bendl, Bin Zhang, Panos Roussos

Research output: Contribution to journalArticlepeer-review

Abstract

Alzheimer’s disease (AD) is the most common form of dementia worldwide, with a projection of 151 million cases by 2050. Previous genetic studies have identified three main genes associated with early-onset familial Alzheimer’s disease, however this subtype accounts for less than 5% of total cases. Next-generation sequencing has been well established and holds great promise to assist in the development of novel therapeutics as well as biomarkers to prevent or slow the progression of this devastating disease. Here we present a public resource of functional genomic data from the parahippocampal gyrus of 201 postmortem control, mild cognitively impaired (MCI) and AD individuals from the Mount Sinai brain bank, of which whole-genome sequencing (WGS), and bulk RNA sequencing (RNA-seq) were previously published. The genomic data include bulk proteomics and DNA methylation, as well as cell-type-specific RNA-seq and assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) data. We have performed extensive preprocessing and quality control, allowing the research community to access and utilize this public resource available on the Synapse platform at https://doi.org/10.7303/syn51180043.2 .

Original languageEnglish (US)
Article number602
JournalScientific Data
Volume10
Issue number1
DOIs
StatePublished - Dec 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023, Springer Nature Limited.

PubMed: MeSH publication types

  • Dataset
  • Journal Article

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