Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia

Keyphrases

• Protein Turnover 100%
• Stereocilia 100%
• Multi-isotope Imaging Mass Spectrometry 100%
• Hair Cell Stereocilia 100%
• Actin 50%
• Hair Cell 40%
• Rapid Turnover 30%
• Overexpression 20%
• Treadmilling 20%
• Inner Ear 10%
• Recombination 10%
• Mechanotransduction 10%
• Chicken 10%
• Frog 10%
• Neonatal Rats 10%
• Tamoxifen Inducible 10%
• Actin-binding Proteins 10%
• Cells in Culture 10%
• Chick 10%
• Fiducial 10%
• Actin Filaments 10%
• GFP Fusion 10%
• Apical Surface 10%
• Breakage 10%
• Labeled Precursors 10%
• Mechanosensory 10%
• Mouse in Vivo 10%
• Actin Isoforms 10%
• Mammalian Hair 10%
• Newly Synthesized Proteins 10%
• Hair Bundle 10%
• Renewing 10%
• Actin Turnover 10%
• Espin 10%
• Tip Link 10%
• Rapid Regulation 10%
• Neonatal Mice 10%
• Precursor Amino Acids 10%
• Animal Life 10%

Biochemistry, Genetics and Molecular Biology

• Protein Degradation 100%
• Imaging Mass Spectrometry 100%
• Stereocilia 100%
• Actin 72%
• Treadmilling 18%
• Isoform 9%
• Amino Acids 9%
• Mechanotransduction 9%
• Precursor 9%
• Chick 9%
• Actin-Binding Protein 9%

Neuroscience

• Mass Spectrometry 100%
• Stereocilia 100%
• Actin 63%
• In Vivo 18%
• Actin Filament 9%
• In Vitro 9%
• Amino Acid 9%
• Actin Binding Protein 9%
• Mechanotransduction 9%
• Tamoxifen 9%