MTOR regulation of autophagy

Chang Hwa Jung, Seung Hyun Ro, Jing Cao, Neil M Otto, Do-Hyung Kim

Research output: Contribution to journalReview article

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Abstract

Nutrient starvation induces autophagy in eukaryotic cells through inhibition of TOR (target of rapamycin), an evolutionarily-conserved protein kinase. TOR, as a central regulator of cell growth, plays a key role at the interface of the pathways that coordinately regulate the balance between cell growth and autophagy in response to nutritional status, growth factor and stress signals. Although TOR has been known as a key regulator of autophagy for more than a decade, the underlying regulatory mechanisms have not been clearly understood. This review discusses the recent advances in understanding of the mechanism by which TOR regulates autophagy with focus on mammalian TOR (mTOR) and its regulation of the autophagy machinery.

Original languageEnglish (US)
Pages (from-to)1287-1295
Number of pages9
JournalFEBS Letters
Volume584
Issue number7
DOIs
StatePublished - Jan 1 2010

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Keywords

  • Autophagy-related gene 1
  • Autophagy-related gene 13
  • Mammalian target of rapamycin
  • UNC-51-like kinase 1
  • UNC-51-like kinase 2

Cite this

Jung, C. H., Ro, S. H., Cao, J., Otto, N. M., & Kim, D-H. (2010). MTOR regulation of autophagy. FEBS Letters, 584(7), 1287-1295. https://doi.org/10.1016/j.febslet.2010.01.017