MTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression

F. Guo, J. Li, S. Zhang, W. Du, S. Amarachintha, J. Sipple, J. Phelan, H. L. Grimes, Y. Zheng, Q. Pang

Research output: Contribution to journalLetterpeer-review

10 Scopus citations
Original languageEnglish (US)
Pages (from-to)203-206
Number of pages4
JournalLeukemia
Volume28
Issue number1
DOIs
StatePublished - 2014

Bibliographical note

Funding Information:
We thank Dr Alan D’Andrea (Harvard Medical School) for the pMMP-Puro and pMMP-FANCD2 retroviral vectors, Dr Xiaoli Li and Jonathan Schick for technical assistance, the Vector Core of the Cincinnati Children’s Research Foundation (Cincinnati Children’s Hospital Medical Center) for the preparation of retroviruses, the Comprehensive Mouse and Cancer Core of the Cincinnati Children’s Research Foundation (Cincinnati Children’s Hospital Medical Center) for bone marrow transplantation service and Leesa Sampson for data analysis. This investigation was supported by NIH grants R01 HL076712, R01 CA157537, P30 DK090971 and T32 HL091805. QP is supported by a Leukemia and Lymphoma Scholar award. WD is supported by a NIH T32 training grant.

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