mTOR at the crossroads of T cell proliferation and tolerance

Anna Mondino; Daniel L. Mueller

doi:10.1016/j.smim.2007.02.008

mTOR at the crossroads of T cell proliferation and tolerance

Anna Mondino, Daniel L. Mueller

Research output: Contribution to journal › Review article › peer-review

93 Scopus citations

Abstract

Several events control the activation, proliferation, and the continued Ag responsiveness of naïve and memory T lymphocytes. Here we review the individual contributions of TCR, CD28, and IL-2-driven signaling to T cell proliferation and anergy avoidance. The role of mTOR as a rheostat capable of integrating extracellular, plasma membrane-associated, and intracellular signals with relevance to T cell priming and tolerance is discussed.

Original language	English (US)
Pages (from-to)	162-172
Number of pages	11
Journal	Seminars in Immunology
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/j.smim.2007.02.008
State	Published - Jun 2007

Keywords

Anergy
CD4+ T cells
Proliferation
mTOR

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10.1016/j.smim.2007.02.008

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title = "mTOR at the crossroads of T cell proliferation and tolerance",

abstract = "Several events control the activation, proliferation, and the continued Ag responsiveness of na{\"i}ve and memory T lymphocytes. Here we review the individual contributions of TCR, CD28, and IL-2-driven signaling to T cell proliferation and anergy avoidance. The role of mTOR as a rheostat capable of integrating extracellular, plasma membrane-associated, and intracellular signals with relevance to T cell priming and tolerance is discussed.",

keywords = "Anergy, CD4+ T cells, Proliferation, mTOR",

author = "Anna Mondino and Mueller, {Daniel L.}",

year = "2007",

month = jun,

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AU - Mondino, Anna

AU - Mueller, Daniel L.

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AB - Several events control the activation, proliferation, and the continued Ag responsiveness of naïve and memory T lymphocytes. Here we review the individual contributions of TCR, CD28, and IL-2-driven signaling to T cell proliferation and anergy avoidance. The role of mTOR as a rheostat capable of integrating extracellular, plasma membrane-associated, and intracellular signals with relevance to T cell priming and tolerance is discussed.

KW - Anergy

KW - CD4+ T cells

KW - Proliferation

KW - mTOR

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ER -

mTOR at the crossroads of T cell proliferation and tolerance

Abstract

Keywords

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