mTOR at the crossroads of T cell proliferation and tolerance

Anna Mondino, Daniel L. Mueller

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations


Several events control the activation, proliferation, and the continued Ag responsiveness of naïve and memory T lymphocytes. Here we review the individual contributions of TCR, CD28, and IL-2-driven signaling to T cell proliferation and anergy avoidance. The role of mTOR as a rheostat capable of integrating extracellular, plasma membrane-associated, and intracellular signals with relevance to T cell priming and tolerance is discussed.

Original languageEnglish (US)
Pages (from-to)162-172
Number of pages11
JournalSeminars in Immunology
Issue number3
StatePublished - Jun 2007


  • Anergy
  • CD4+ T cells
  • Proliferation
  • mTOR


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