MRI morphometric analysis and neuropsychological function in patients with neurofibromatosis

Sameh M.A. Said, Tzung Lieh Yeh, Robert S. Greenwood, J. Kenneth Whitt, Larry A. Tupler, K. Ranga R. Krishnan

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Volumes of cerebral gray and white matter were measured in 22 children with neurofibromatosis type 1 (NF1) and in 20 controls. Judgment of Line Orientation (JLO) and the Developmental Test of Visual-Motor Integration (DTVMI) were administered to 16 of the NF1 patients. General linear models analysis of covariance revealed significantly larger brain volumes in NF1 children than in controls, particularly in white matter, and particularly in girls. JLO and DTVMI performance were positively related to right-hemisphere gray-matter volume. The results implicate a failure of growth control in NF1, leading to aberrant neurodevelopment. Our findings also suggest a basis for refined understanding of learning disabilities, which are a prominent feature of NF1.

Original languageEnglish (US)
Pages (from-to)1941-1944
Number of pages4
Issue number12
StatePublished - 1996
Externally publishedYes


  • gray-matter
  • magnetic resonance imaging (MRI)
  • neurofibromatosis
  • neuropsychological function
  • white matter
  • whole-brain volume


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