MR Microimaging of amyloid plaques in Alzheimer's disease transgenic mice

Thomas M. Wengenack, Clifford R. Jack, Michael Garwood, Joseph F. Poduslo

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Introduction: Alzheimer's disease (AD) is the most prevalent neurological condition affecting industrialized nations and will rapidly become a healthcare crisis as the population ages. Currently, the post-mortem histological observation of amyloid plaques and neurofibrillary tangles is the only definitive diagnosis available for AD. A pre-mortem biological or physiological marker specific for AD used in conjunction with current neurological and memory testing could add a great deal of confidence to the diagnosis of AD and potentially allow therapeutic intervention much earlier in the disease process. Discussion and conclusion: Our group has developed MRI techniques to detect individual amyloid plaques in AD transgenic mouse brain in vivo. We are also developing contrast-enhancing agents to increase the specificity of detection of amyloid plaques. Such in vivo imaging of amyloid plaques will also allow the evaluation of anti-amyloid therapies being developed by the pharmaceutical industry in pre-clinical trials of AD transgenic mice. This short review briefly discusses our progress in these areas.

Original languageEnglish (US)
Pages (from-to)S82-S88
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume35
Issue numberSUPPL. 1
DOIs
StatePublished - Mar 2008

Bibliographical note

Funding Information:
Acknowledgements This work was supported by the National Institutes of Health grants AG22034 (JFP), P41 RR008079 (MG), and P30 NS057091 (MG), and the Minnesota Partnership for Biotechnology and Medical Genomics.

Keywords

  • Alzheimer's disease
  • Amyloid-β
  • Magnetic resonance imaging
  • Plaque
  • Transgenic mouse

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