MR measurements of Gd-DTPA kinetics for estimation of myocardial perfusion

T. Machnig, N. Wilke, G. Engels, K. Bachmann, F. C. Simm, J. Ellermann, J. Zhang, X. Ya, H. Merkel, G. Path, R. J. Bache, K. Ugurbil

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

By administering gadolinium-diethylenetriamine-penta-acetic acid (Gd-DTPA) in conjunction with the Turbo-Flash sequence, the authors assessed the potential of dynamic contrast-enhanced ultrafast magnetic resonance imaging (MRI) to detect and quantify reductions in myocardial perfusion secondary to stenosis and hyperemia induced by Dipyridamole. In ten subjects and three dogs signal intensity-time curves were generated in regions of interest over myocardium. An one-compartment model was introduced to describe the kinetics of Gd-DTPA. The first results indicate that measurements of Gd-DPTA kinetics seem of potential value for the non-invasive assessment of myocardial perfusion.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
PublisherPubl by IEEE
Pages5-8
Number of pages4
ISBN (Print)081862485X
StatePublished - Jan 1 1992
EventProceedings of the 18th Annual Conference on Computers in Cardiology - Venice, Italy
Duration: Sep 23 1991Sep 26 1991

Publication series

NameComputers in Cardiology
ISSN (Print)0276-6574

Other

OtherProceedings of the 18th Annual Conference on Computers in Cardiology
CityVenice, Italy
Period9/23/919/26/91

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