MR measurements of Gd-DTPA kinetics for estimation of myocardial perfusion

T. Machnig, N. Wilke, G. Engels, K. Bachmann, F. C. Simm, J. Ellermann, J. Zhang, X. Ya, H. Merkel, G. Path, Robert J Bache, K. Ugurbil

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

By administering gadolinium-diethylenetriamine-penta-acetic acid (Gd-DTPA) in conjunction with the Turbo-Flash sequence, the authors assessed the potential of dynamic contrast-enhanced ultrafast magnetic resonance imaging (MRI) to detect and quantify reductions in myocardial perfusion secondary to stenosis and hyperemia induced by Dipyridamole. In ten subjects and three dogs signal intensity-time curves were generated in regions of interest over myocardium. An one-compartment model was introduced to describe the kinetics of Gd-DTPA. The first results indicate that measurements of Gd-DPTA kinetics seem of potential value for the non-invasive assessment of myocardial perfusion.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
PublisherPubl by IEEE
Pages5-8
Number of pages4
ISBN (Print)081862485X
StatePublished - 1992
EventProceedings of the 18th Annual Conference on Computers in Cardiology - Venice, Italy
Duration: Sep 23 1991Sep 26 1991

Publication series

NameComputers in Cardiology
ISSN (Print)0276-6574

Other

OtherProceedings of the 18th Annual Conference on Computers in Cardiology
CityVenice, Italy
Period9/23/919/26/91

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