MR imaging contrast enhancement based on intermolecular zero quantum coherences

Warren S. Warren, Sangdoo Ahn, Marlene Mescher, Michael Garwood, Kamil Ugurbil, Wolfgang Richter, Rahim R. Rizi, Jeff Hopkins, John S. Leigh

Research output: Contribution to journalArticlepeer-review

164 Scopus citations


A new method for magnetic resonance imaging (MRI) based on the detection of relatively strong signal from intermolecular zero-quantum coherences (iZQCs) is reported. Such a signal would not be observable in the conventional framework of magnetic resonance; it originates in long-range dipolar couplings (10 micrometers to 1 millimeter) that are traditionally ignored. Unlike conventional MRI, where image contrast is based on variations in spin density and relaxation times (often with injected contrast agents), contrast with iZQC images comes from variations in the susceptibility over a distance dictated by gradient strength. Phantom and in vivo (rat brain) data confirm that iZQC images give contrast enhancement. This contrast might be useful in the detection of small tumors, in that susceptibility correlates with oxygen concentration and in functional MRI.

Original languageEnglish (US)
Pages (from-to)247-251
Number of pages5
Issue number5374
StatePublished - Jul 10 1998


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