MR imaging contrast enhancement based on intermolecular zero quantum coherences

Warren S. Warren; Sangdoo Ahn; Marlene Mescher; Michael Garwood; Kamil Ugurbil; Wolfgang Richter; Rahim R. Rizi; Jeff Hopkins; John S. Leigh

doi:10.1126/science.281.5374.247

MR imaging contrast enhancement based on intermolecular zero quantum coherences

Warren S. Warren, Sangdoo Ahn, Marlene Mescher, Michael Garwood, Kamil Ugurbil, Wolfgang Richter, Rahim R. Rizi, Jeff Hopkins, John S. Leigh

Research output: Contribution to journal › Article › peer-review

177 Scopus citations

Abstract

A new method for magnetic resonance imaging (MRI) based on the detection of relatively strong signal from intermolecular zero-quantum coherences (iZQCs) is reported. Such a signal would not be observable in the conventional framework of magnetic resonance; it originates in long-range dipolar couplings (10 micrometers to 1 millimeter) that are traditionally ignored. Unlike conventional MRI, where image contrast is based on variations in spin density and relaxation times (often with injected contrast agents), contrast with iZQC images comes from variations in the susceptibility over a distance dictated by gradient strength. Phantom and in vivo (rat brain) data confirm that iZQC images give contrast enhancement. This contrast might be useful in the detection of small tumors, in that susceptibility correlates with oxygen concentration and in functional MRI.

Original language	English (US)
Pages (from-to)	247-251
Number of pages	5
Journal	Science
Volume	281
Issue number	5374
DOIs	https://doi.org/10.1126/science.281.5374.247
State	Published - Jul 10 1998

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abstract = "A new method for magnetic resonance imaging (MRI) based on the detection of relatively strong signal from intermolecular zero-quantum coherences (iZQCs) is reported. Such a signal would not be observable in the conventional framework of magnetic resonance; it originates in long-range dipolar couplings (10 micrometers to 1 millimeter) that are traditionally ignored. Unlike conventional MRI, where image contrast is based on variations in spin density and relaxation times (often with injected contrast agents), contrast with iZQC images comes from variations in the susceptibility over a distance dictated by gradient strength. Phantom and in vivo (rat brain) data confirm that iZQC images give contrast enhancement. This contrast might be useful in the detection of small tumors, in that susceptibility correlates with oxygen concentration and in functional MRI.",

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AU - Warren, Warren S.

AU - Ahn, Sangdoo

AU - Mescher, Marlene

AU - Garwood, Michael

AU - Ugurbil, Kamil

AU - Richter, Wolfgang

AU - Rizi, Rahim R.

AU - Hopkins, Jeff

AU - Leigh, John S.

PY - 1998/7/10

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AB - A new method for magnetic resonance imaging (MRI) based on the detection of relatively strong signal from intermolecular zero-quantum coherences (iZQCs) is reported. Such a signal would not be observable in the conventional framework of magnetic resonance; it originates in long-range dipolar couplings (10 micrometers to 1 millimeter) that are traditionally ignored. Unlike conventional MRI, where image contrast is based on variations in spin density and relaxation times (often with injected contrast agents), contrast with iZQC images comes from variations in the susceptibility over a distance dictated by gradient strength. Phantom and in vivo (rat brain) data confirm that iZQC images give contrast enhancement. This contrast might be useful in the detection of small tumors, in that susceptibility correlates with oxygen concentration and in functional MRI.

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MR imaging contrast enhancement based on intermolecular zero quantum coherences

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