Movemena kinematics encoded in complex spike discharge of primate cerebellar Purkinje cells

Qing Gong Fu, Carolyn R. Mason, Didier Flament, Jonathon D. Coltz, Timothy J. Ebner

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Monkeys performed a multijoint arm-reaching task that systematically varied movement direction and distance. Purkinje cell activity was recorded from 231 task-related cells, and the complex spike discharge was analyzed in relation to distance and direction. The complex spike activity of 123 Purkinje cells changed significantly relative to the background rate. Of these 123, the activity of 85 cells was related to distance and/or direction. The complex spilte activity of 54 of these 85 cells fitted a cosine tuning curve for direction, generally at one distance. Using a simple linear regression model, the complex spike activity of 56 cells was significantly correlated with movement distance, usually in one direction. We conclude that the complex spike discharge of Purkinje cells is spatially tuned and strongly related to movement kinematics.

Original languageEnglish (US)
Pages (from-to)523-529
Number of pages7
JournalNeuroreport
Volume8
Issue number2
DOIs
StatePublished - 1997

Keywords

  • Arm movement
  • Cerebellum
  • Complex spikes
  • Direction
  • Distance
  • Kinematics
  • Monkey
  • Motor control
  • Reaching

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