Mouse models of accelerated cellular senescence

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Senescent cells accumulate in multiple tissues as virtually all vertebrate organisms age. Senescence is a highly conserved response to many forms of cellular stress intended to block the propagation of damaged cells. Senescent cells have been demonstrated to play a causal role in aging via their senescence-associated secretory phenotype and by impeding tissue regeneration. Depletion of senescent cells either through genetic or pharmacologic methods has been demonstrated to extend murine lifespan and delay the onset of age-related diseases. Measuring the burden and location of senescent cells in vivo remains challenging, as there is no marker unique to senescent cells. Here, we describe multiple methods to detect the presence and extent of cellular senescence in preclinical models, with a special emphasis on murine models of accelerated aging that exhibit a more rapid onset of cellular senescence.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages203-230
Number of pages28
DOIs
StatePublished - Jan 1 2019

Publication series

NameMethods in Molecular Biology
Volume1896
ISSN (Print)1064-3745

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Keywords

  • Aging
  • Biomarkers
  • Gene expression
  • Murine models
  • Progeria
  • Senescence

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

Cite this

Yousefzadeh, M., Melos, K. I., Angelini, L., Burd, C. E., Robbins, P. D., & Niedernhofer, L. J. (2019). Mouse models of accelerated cellular senescence. In Methods in Molecular Biology (pp. 203-230). (Methods in Molecular Biology; Vol. 1896). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-8931-7_17