TY - JOUR
T1 - Motoric cognitive risk syndrome Multicountry prevalence and dementia risk
AU - Verghese, Joe
AU - Annweiler, Cedric
AU - Ayers, Emmeline
AU - Barzilai, Nir
AU - Beauchet, Olivier
AU - Bennett, David A.
AU - Bridenbaugh, Stephanie A.
AU - Buchman, Aron S.
AU - Callisaya, Michele L.
AU - Camicioli, Richard
AU - Capistrant, Benjamin
AU - Chatterji, Somnath
AU - De Cock, Anne Marie
AU - Ferrucci, Luigi
AU - Giladi, Nir
AU - Guralnik, Jack M.
AU - Hausdorff, Jeffrey M.
AU - Holtzer, Roee
AU - Kim, Ki Woong
AU - Kowal, Paul
AU - Kressig, Reto W.
AU - Lim, Jae Young
AU - Lord, Susan
AU - Meguro, Kenichi
AU - Montero-Odasso, Manuel
AU - Muir-Hunter, Susan W.
AU - Noone, Mohan L.
AU - Rochester, Lynn
AU - Srikanth, Velandai
AU - Wang, Cuiling
N1 - Publisher Copyright:
© 2014 American Academy of Neurology.
PY - 2014/8/19
Y1 - 2014/8/19
N2 - Objectives: Our objective is to report prevalence of motoric cognitive risk syndrome (MCR), a newly described predementia syndrome characterized by slow gait and cognitive complaints, in multiple countries, and its association with dementia risk.Methods: Pooled MCR prevalence analysis of individual data from 26,802 adults without dementia and disability aged 60 years and older from 22 cohorts from 17 countries. We also examined risk of incident cognitive impairment (Mini-Mental State Examination decline ≥ 4 points) and dementia associated with MCR in 4,812 individuals without dementia with baseline Mini- Mental State Examination scores ≥25 from 4 prospective cohort studies using Cox models adjusted for potential confounders.Results: At baseline, 2,808 of the 26,802 participants met MCR criteria. PooledMCR prevalence was 9.7% (95% confidence interval [CI] 8.2%-11.2%). MCR prevalence was higher with older age but there were no sex differences. MCR predicted risk of developing incident cognitive impairment in the pooled sample (adjusted hazard ratio [aHR] 2.0, 95% CI 1.7-2.4); aHRs were 1.5 to 2.7 in the individual cohorts. MCR also predicted dementia in the pooled sample (aHR 1.9, 95% CI 1.5-2.3). The results persisted even after excluding participants with possible cognitive impairment, accounting for early dementia, and diagnostic overlap with other predementia syndromes.Conclusion: MCR is common in older adults, and is a strong and early risk factor for cognitive decline. This clinical approach can be easily applied to identify high-risk seniors in a wide variety of settings.
AB - Objectives: Our objective is to report prevalence of motoric cognitive risk syndrome (MCR), a newly described predementia syndrome characterized by slow gait and cognitive complaints, in multiple countries, and its association with dementia risk.Methods: Pooled MCR prevalence analysis of individual data from 26,802 adults without dementia and disability aged 60 years and older from 22 cohorts from 17 countries. We also examined risk of incident cognitive impairment (Mini-Mental State Examination decline ≥ 4 points) and dementia associated with MCR in 4,812 individuals without dementia with baseline Mini- Mental State Examination scores ≥25 from 4 prospective cohort studies using Cox models adjusted for potential confounders.Results: At baseline, 2,808 of the 26,802 participants met MCR criteria. PooledMCR prevalence was 9.7% (95% confidence interval [CI] 8.2%-11.2%). MCR prevalence was higher with older age but there were no sex differences. MCR predicted risk of developing incident cognitive impairment in the pooled sample (adjusted hazard ratio [aHR] 2.0, 95% CI 1.7-2.4); aHRs were 1.5 to 2.7 in the individual cohorts. MCR also predicted dementia in the pooled sample (aHR 1.9, 95% CI 1.5-2.3). The results persisted even after excluding participants with possible cognitive impairment, accounting for early dementia, and diagnostic overlap with other predementia syndromes.Conclusion: MCR is common in older adults, and is a strong and early risk factor for cognitive decline. This clinical approach can be easily applied to identify high-risk seniors in a wide variety of settings.
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U2 - 10.1212/WNL.0000000000000717
DO - 10.1212/WNL.0000000000000717
M3 - Article
C2 - 25031288
AN - SCOPUS:84920566632
SN - 0028-3878
VL - 83
SP - 718
EP - 726
JO - Neurology
JF - Neurology
IS - 8
ER -