Motor unit number estimation

Research output: Chapter in Book/Report/Conference proceedingChapter


Due to the anatomic location of motor neurons, it is has not been possible to directly quantify motor neuron loss in anterior horn cell disease. Motor neurons are located in the anterior spinal cord, one of the areas within the nervous system that are not amenable to biopsy and histological analysis in living patients. The spinal cord has a high density of eloquent fiber tracts. Biopsy-induced injury to these tracts would result in significant weakness, paraesthesiae and/or sphincter dysfunction. As a result, estimating the degree of actual motor neuron loss has remained elusive for motor neuron diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Motor unit number estimation (MUNE) provides a reliable estimate of the number of functional motor units present in such diseases.

Original languageEnglish (US)
Title of host publicationPediatric Electromyography
Subtitle of host publicationConcepts and Clinical Applications
PublisherSpringer International Publishing
Number of pages5
ISBN (Electronic)9783319613611
ISBN (Print)9783319613604
StatePublished - Oct 27 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© Springer International Publishing AG 2017. All rights reserved.


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