Motor execution and imagination networks in post-stroke dystonia

Stéphane Lehéricy, Emmanuel Gerardin, Jean Baptiste Poline, Sabine Meunier, Pierre Francois Van De Moortele, Denis Le Bihan, Marie Vidailhet

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Reorganization of motor execution and imagination networks was studied in six patients with unilateral dystonia secondary to a subcortical stroke and compared with seven control subjects using fMRI. Patients performed imagined and real auditory-cued hand movements. Movements of the dystonic hand resulted in overactivity in bilateral motor, premotor, and prefrontal cortex, insula, precuneus, and cerebellum, in parietal areas and the striatum contralateral to the lesion. Movements of the unaffected hand resulted in overactivity in bilateral preSMA, prefrontal, and parietal areas, insula and cerebellum, the ipsilateral premotor cortex and the contralateral striatum to the lesion. Mental representation of movements with each hand resulted in overactivity in bilateral parietal, premotor and prefrontal areas. These results suggest that execution and mental representation of movement are altered in these patients.

Original languageEnglish (US)
Pages (from-to)1887-1890
Number of pages4
JournalNeuroreport
Volume15
Issue number12
DOIs
StatePublished - Aug 26 2004

Keywords

  • Basal ganglia
  • Dystonia
  • Functional magnetic resonance imaging
  • Motor system
  • Stroke

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