Motor cortex brain activity induced by 1-Hz transcranial magnetic stimulation is similar in location and level to that for volitional movement

Daryl E. Bohning, Ananda Shastri, Lucy McGAVIN, Kathleen A. McConnell, Ziad Nahas, Jeffrey P. Lorberbaum, Donna R. Roberts, Mark S. George

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

RATIONALE AND OBJECTIVES. The relatively high temporal and spatial resolution of functional MR imaging was used to compare the blood oxygenation level dependent (BOLD) response associated with movement induced by transcranial magnetic stimulation (TMS) with that for a similar movement executed volitionaily (VOL). METHODS. Seven healthy adults were studied in a 1.5-T MR scanner. One hertz TMS at 110% of motor threshold was applied over the motor cortex for the thumb in 21-pulse trains in alternation with VOL every 63 seconds and interleaved with functional MR imaging. RESULTS. BOLD increases in motor cortex associated with TMS and VOL movement were similar (2%-3%). Mean separation of their centers of activity was 3.7 ± 1.9 mm (mean displacement: Left/right = 0.3 ± 4.1 mm; superior/inferior = 0.7 ± 1.9 mm). There was no indication of supraphysiological brain activity. CONCLUSIONS. Motor cortex BOLD response associated with thumb movement induced by 1-Hz TMS at 110% motor threshold is similar in both location and level to that caused by a similar movement executed volitionally.

Original languageEnglish (US)
Pages (from-to)676-683
Number of pages8
JournalInvestigative Radiology
Volume35
Issue number11
DOIs
StatePublished - Nov 25 2000

Keywords

  • Motor cortex, volitional movement, blood flow, imaging
  • Transcranial magnetic stimulation, functional MR imaging, human

Fingerprint Dive into the research topics of 'Motor cortex brain activity induced by 1-Hz transcranial magnetic stimulation is similar in location and level to that for volitional movement'. Together they form a unique fingerprint.

Cite this