Motor control in basal ganglia circuits using fMRI and brain atlas approaches

Stéphane Lehéricy, Eric Bardinet, Leon Tremblay, Pierre Francois Van De Moortele, Jean Baptiste Pochon, Didier Dormont, Dae Shik Kim, Jerome Yelnik, Kamil Ugurbil

Research output: Contribution to journalArticlepeer-review

182 Scopus citations

Abstract

In this study, we examined how the motor, premotor and associative basal ganglia territories process movement parameters such as the complexity and the frequency of movement. Twelve right-handed volunteers were studied using EPI BOLD contrast (3 T) while performing audio-paced finger tapping tasks designed to differentiate basal ganglia territories. Tasks varied movement complexity (repetitive index tapping, simple sequence of finger movements and complex sequence of 10 moves) and frequency (from 0.5 to 3 Hz). Activation maps were coregistered onto a 3-D brain atlas derived from post-mortem brains. Three main patterns of activation were observed. In the posterior putamen and the sensorimotor cortex, signal increased with movement frequency but not with movement complexity. In premotor areas, the anterior putamen and the ventral posterolateral thalamus, signal increased regularly with increasing movement frequency and complexity. In rostral frontal areas, the caudate nucleus, the subthalamic nucleus and the ventral anterior/ ventrolateral thalamus, signal increased mainly during the complex task and the high frequency task (3 Hz). These data show the different roles of motor, premotor and associative basal ganglia circuits in the processing of motor-related operations and suggest that activation can be precisely located within the entire circuitry of the basal ganglia.

Original languageEnglish (US)
Pages (from-to)149-161
Number of pages13
JournalCerebral Cortex
Volume16
Issue number2
DOIs
StatePublished - Feb 2006

Bibliographical note

Funding Information:
This study was supported by grants from NIH (BTRR P41-RR08079 and RO1 EB000331), the Keck Foundation, the MIND Institute, the Human Frontiers Science Program, and the Action Concertée Incitative 2001-6503H. We thank Malgorzata Marjanska for reviewing the manuscript.

Keywords

  • Basal ganglia
  • Globus pallidus
  • Motor system
  • Movement frequency
  • Subthalamic nucleus

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