Most microbe-specific naïve CD4+ T cells produce memory cells during infection

Noah J. Tubo, Brian T. Fife, Antonio J. Pagan, Dmitri I. Kotov, Michael F. Goldberg, Marc K. Jenkins

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Infection elicits CD4+ memory T lymphocytes that participate in protective immunity. Although memory cells are the progeny of naïve T cells, it is unclear that all naïve cells from a polyclonal repertoire have memory cell potential. Using a single-cell adoptive transfer and spleen biopsy method, we found that in mice, essentially all microbe-specific naïve cells produced memory cells during infection. Different clonal memory cell populations had different B cell or macrophage helper compositions that matched effector cell populations generated much earlier in the response. Thus, each microbe-specific naïve CD4+ T cell produces a distinctive ratio of effector cell types early in the immune response that is maintained as some cells in the clonal population become memory cells.

Original languageEnglish (US)
Pages (from-to)511-514
Number of pages4
JournalScience
Volume351
Issue number6272
DOIs
StatePublished - Jan 29 2016

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