Mosquito large subunit ribosomal RNA: simultaneous alignment of primary and secondary structure

K. M. Kjer, G. D. Baldridge, A. M. Fallon

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

We report the sequence and propose a secondary structure for the cytoplasmic large subunit (5.8S and 28S) ribosomal RNA of the mosquito, Aedes albopictus, in an aligned format that incorporates secondary structure comparisons with Homo sapiens, Drosophila melanogaster, and Escherichia coli ribosomal RNAs. This format facilitates comparison of subtle differences between models, allowing nucleotide by nucleotide analysis at each position of discrepancy. Comparison of the A. albopictus large subunit ribosomal RNA gene with those from other species revealed new compensatory base changes. The aligned format focuses attention to the specific contribution of the A. albopictus sequence by facilitating comparison with the sequence of another dipteran, D. melanogaster. This is the second report of a complete large subunit rRNA sequence from an arthropod, and the first 28S rRNA sequence for a member of the lower Diptera (Nematocera).

Original languageEnglish (US)
Pages (from-to)147-155
Number of pages9
JournalBBA - Gene Structure and Expression
Volume1217
Issue number2
DOIs
StatePublished - Mar 1 1994

Keywords

  • (Mosquito)
  • RNA structure
  • Ribosomal RNA
  • Ribosome
  • Secondary structure
  • rRNA sequence

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