Mosquito large subunit ribosomal RNA: simultaneous alignment of primary and secondary structure

K. M. Kjer, G. D. Baldridge, A. M. Fallon

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


We report the sequence and propose a secondary structure for the cytoplasmic large subunit (5.8S and 28S) ribosomal RNA of the mosquito, Aedes albopictus, in an aligned format that incorporates secondary structure comparisons with Homo sapiens, Drosophila melanogaster, and Escherichia coli ribosomal RNAs. This format facilitates comparison of subtle differences between models, allowing nucleotide by nucleotide analysis at each position of discrepancy. Comparison of the A. albopictus large subunit ribosomal RNA gene with those from other species revealed new compensatory base changes. The aligned format focuses attention to the specific contribution of the A. albopictus sequence by facilitating comparison with the sequence of another dipteran, D. melanogaster. This is the second report of a complete large subunit rRNA sequence from an arthropod, and the first 28S rRNA sequence for a member of the lower Diptera (Nematocera).

Original languageEnglish (US)
Pages (from-to)147-155
Number of pages9
JournalBBA - Gene Structure and Expression
Issue number2
StatePublished - Mar 1 1994

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health grant AI 20385, the Alexander P. and Lydia Anderson Fellowship (K.M.K.) and by the University of Minnesota Agricultural Experiment Station. This is publication 20,077 from the University of Minnesota experiment station, St. Paul, MN.


  • (Mosquito)
  • RNA structure
  • Ribosomal RNA
  • Ribosome
  • Secondary structure
  • rRNA sequence


Dive into the research topics of 'Mosquito large subunit ribosomal RNA: simultaneous alignment of primary and secondary structure'. Together they form a unique fingerprint.

Cite this