Mortality after breast cancer among survivors of childhood cancer

A report from the Childhood Cancer Survivor Study

Chaya S. Moskowitz, Joanne F. Chou, Joseph P Neglia, Ann H. Partridge, Rebecca M. Howell, Lisa R. Diller, Danielle Novetsky Friedman, Dana Barnea, Lindsay M. Morton, Lucie M Turcotte, Michael A. Arnold, Wendy M. Leisenring, Gregory T. Armstrong, Leslie L. Robison, Kevin C. Oeffinger, Tara O. Henderson

Research output: Contribution to journalArticle

Abstract

PURPOSE Female survivors of childhood cancer have a high risk of subsequent breast cancer. We describe the ensuing risk for mortality and additional breast cancers. PATIENTS AND METHODS Female participants in the Childhood Cancer Survivor Study, a cohort of 5-year survivors of cancer diagnosed between 1970 and 1986 before age 21 years, and subsequently diagnosed with breast cancer (n = 274; median age at breast cancer diagnosis, 38 years; range, 20 to 58 years) were matched to a control group (n = 1,095) with de novo breast cancer. Hazard ratios (HRs) and 95% CIs were estimated from cause-specific proportional hazards models. RESULTS Ninety-two childhood cancer survivors died, 49 as a result of breast cancer. Overall survival after breast cancer was 73% by 10 years. Subsequent risk of death as a result of any cause was higher among childhood cancer survivors than among controls (HR, 2.2; 95% CI, 1.7 to 3.0) and remained elevated after adjusting for breast cancer treatment (HR, 2.4; 95% CI, 1.7 to 3.2). Although breast cancer–specific mortality was modestly elevated among childhood cancer survivors (HR, 1.3; 95% CI, 0.9 to 2.0), survivors were five times more likely to die as a result of other health-related causes, including other subsequent malignant neoplasms and cardiovascular or pulmonary disease (HR, 5.5; 95% CI, 3.4 to 9.0). The cumulative incidence of a second asynchronous breast cancer also was elevated significantly compared with controls (P, .001). CONCLUSION Mortality after breast cancer was higher in childhood cancer survivors than in women with de novo breast cancer. This increased mortality reflects the burden of comorbidity and highlights the need for risk-reducing interventions.

Original languageEnglish (US)
Pages (from-to)2120-2130
Number of pages11
JournalJournal of Clinical Oncology
Volume37
Issue number24
DOIs
StatePublished - Aug 20 2019

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Survivors
Breast Neoplasms
Mortality
Neoplasms
Safety Management
Proportional Hazards Models
Lung Diseases
Comorbidity
Breast
Cohort Studies
Cardiovascular Diseases
Control Groups
Survival
Incidence
Health

PubMed: MeSH publication types

  • Journal Article

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Moskowitz, C. S., Chou, J. F., Neglia, J. P., Partridge, A. H., Howell, R. M., Diller, L. R., ... Henderson, T. O. (2019). Mortality after breast cancer among survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Journal of Clinical Oncology, 37(24), 2120-2130. https://doi.org/10.1200/JCO.18.02219

Mortality after breast cancer among survivors of childhood cancer : A report from the Childhood Cancer Survivor Study. / Moskowitz, Chaya S.; Chou, Joanne F.; Neglia, Joseph P; Partridge, Ann H.; Howell, Rebecca M.; Diller, Lisa R.; Friedman, Danielle Novetsky; Barnea, Dana; Morton, Lindsay M.; Turcotte, Lucie M; Arnold, Michael A.; Leisenring, Wendy M.; Armstrong, Gregory T.; Robison, Leslie L.; Oeffinger, Kevin C.; Henderson, Tara O.

In: Journal of Clinical Oncology, Vol. 37, No. 24, 20.08.2019, p. 2120-2130.

Research output: Contribution to journalArticle

Moskowitz, CS, Chou, JF, Neglia, JP, Partridge, AH, Howell, RM, Diller, LR, Friedman, DN, Barnea, D, Morton, LM, Turcotte, LM, Arnold, MA, Leisenring, WM, Armstrong, GT, Robison, LL, Oeffinger, KC & Henderson, TO 2019, 'Mortality after breast cancer among survivors of childhood cancer: A report from the Childhood Cancer Survivor Study', Journal of Clinical Oncology, vol. 37, no. 24, pp. 2120-2130. https://doi.org/10.1200/JCO.18.02219
Moskowitz, Chaya S. ; Chou, Joanne F. ; Neglia, Joseph P ; Partridge, Ann H. ; Howell, Rebecca M. ; Diller, Lisa R. ; Friedman, Danielle Novetsky ; Barnea, Dana ; Morton, Lindsay M. ; Turcotte, Lucie M ; Arnold, Michael A. ; Leisenring, Wendy M. ; Armstrong, Gregory T. ; Robison, Leslie L. ; Oeffinger, Kevin C. ; Henderson, Tara O. / Mortality after breast cancer among survivors of childhood cancer : A report from the Childhood Cancer Survivor Study. In: Journal of Clinical Oncology. 2019 ; Vol. 37, No. 24. pp. 2120-2130.
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abstract = "PURPOSE Female survivors of childhood cancer have a high risk of subsequent breast cancer. We describe the ensuing risk for mortality and additional breast cancers. PATIENTS AND METHODS Female participants in the Childhood Cancer Survivor Study, a cohort of 5-year survivors of cancer diagnosed between 1970 and 1986 before age 21 years, and subsequently diagnosed with breast cancer (n = 274; median age at breast cancer diagnosis, 38 years; range, 20 to 58 years) were matched to a control group (n = 1,095) with de novo breast cancer. Hazard ratios (HRs) and 95{\%} CIs were estimated from cause-specific proportional hazards models. RESULTS Ninety-two childhood cancer survivors died, 49 as a result of breast cancer. Overall survival after breast cancer was 73{\%} by 10 years. Subsequent risk of death as a result of any cause was higher among childhood cancer survivors than among controls (HR, 2.2; 95{\%} CI, 1.7 to 3.0) and remained elevated after adjusting for breast cancer treatment (HR, 2.4; 95{\%} CI, 1.7 to 3.2). Although breast cancer–specific mortality was modestly elevated among childhood cancer survivors (HR, 1.3; 95{\%} CI, 0.9 to 2.0), survivors were five times more likely to die as a result of other health-related causes, including other subsequent malignant neoplasms and cardiovascular or pulmonary disease (HR, 5.5; 95{\%} CI, 3.4 to 9.0). The cumulative incidence of a second asynchronous breast cancer also was elevated significantly compared with controls (P, .001). CONCLUSION Mortality after breast cancer was higher in childhood cancer survivors than in women with de novo breast cancer. This increased mortality reflects the burden of comorbidity and highlights the need for risk-reducing interventions.",
author = "Moskowitz, {Chaya S.} and Chou, {Joanne F.} and Neglia, {Joseph P} and Partridge, {Ann H.} and Howell, {Rebecca M.} and Diller, {Lisa R.} and Friedman, {Danielle Novetsky} and Dana Barnea and Morton, {Lindsay M.} and Turcotte, {Lucie M} and Arnold, {Michael A.} and Leisenring, {Wendy M.} and Armstrong, {Gregory T.} and Robison, {Leslie L.} and Oeffinger, {Kevin C.} and Henderson, {Tara O.}",
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T1 - Mortality after breast cancer among survivors of childhood cancer

T2 - A report from the Childhood Cancer Survivor Study

AU - Moskowitz, Chaya S.

AU - Chou, Joanne F.

AU - Neglia, Joseph P

AU - Partridge, Ann H.

AU - Howell, Rebecca M.

AU - Diller, Lisa R.

AU - Friedman, Danielle Novetsky

AU - Barnea, Dana

AU - Morton, Lindsay M.

AU - Turcotte, Lucie M

AU - Arnold, Michael A.

AU - Leisenring, Wendy M.

AU - Armstrong, Gregory T.

AU - Robison, Leslie L.

AU - Oeffinger, Kevin C.

AU - Henderson, Tara O.

PY - 2019/8/20

Y1 - 2019/8/20

N2 - PURPOSE Female survivors of childhood cancer have a high risk of subsequent breast cancer. We describe the ensuing risk for mortality and additional breast cancers. PATIENTS AND METHODS Female participants in the Childhood Cancer Survivor Study, a cohort of 5-year survivors of cancer diagnosed between 1970 and 1986 before age 21 years, and subsequently diagnosed with breast cancer (n = 274; median age at breast cancer diagnosis, 38 years; range, 20 to 58 years) were matched to a control group (n = 1,095) with de novo breast cancer. Hazard ratios (HRs) and 95% CIs were estimated from cause-specific proportional hazards models. RESULTS Ninety-two childhood cancer survivors died, 49 as a result of breast cancer. Overall survival after breast cancer was 73% by 10 years. Subsequent risk of death as a result of any cause was higher among childhood cancer survivors than among controls (HR, 2.2; 95% CI, 1.7 to 3.0) and remained elevated after adjusting for breast cancer treatment (HR, 2.4; 95% CI, 1.7 to 3.2). Although breast cancer–specific mortality was modestly elevated among childhood cancer survivors (HR, 1.3; 95% CI, 0.9 to 2.0), survivors were five times more likely to die as a result of other health-related causes, including other subsequent malignant neoplasms and cardiovascular or pulmonary disease (HR, 5.5; 95% CI, 3.4 to 9.0). The cumulative incidence of a second asynchronous breast cancer also was elevated significantly compared with controls (P, .001). CONCLUSION Mortality after breast cancer was higher in childhood cancer survivors than in women with de novo breast cancer. This increased mortality reflects the burden of comorbidity and highlights the need for risk-reducing interventions.

AB - PURPOSE Female survivors of childhood cancer have a high risk of subsequent breast cancer. We describe the ensuing risk for mortality and additional breast cancers. PATIENTS AND METHODS Female participants in the Childhood Cancer Survivor Study, a cohort of 5-year survivors of cancer diagnosed between 1970 and 1986 before age 21 years, and subsequently diagnosed with breast cancer (n = 274; median age at breast cancer diagnosis, 38 years; range, 20 to 58 years) were matched to a control group (n = 1,095) with de novo breast cancer. Hazard ratios (HRs) and 95% CIs were estimated from cause-specific proportional hazards models. RESULTS Ninety-two childhood cancer survivors died, 49 as a result of breast cancer. Overall survival after breast cancer was 73% by 10 years. Subsequent risk of death as a result of any cause was higher among childhood cancer survivors than among controls (HR, 2.2; 95% CI, 1.7 to 3.0) and remained elevated after adjusting for breast cancer treatment (HR, 2.4; 95% CI, 1.7 to 3.2). Although breast cancer–specific mortality was modestly elevated among childhood cancer survivors (HR, 1.3; 95% CI, 0.9 to 2.0), survivors were five times more likely to die as a result of other health-related causes, including other subsequent malignant neoplasms and cardiovascular or pulmonary disease (HR, 5.5; 95% CI, 3.4 to 9.0). The cumulative incidence of a second asynchronous breast cancer also was elevated significantly compared with controls (P, .001). CONCLUSION Mortality after breast cancer was higher in childhood cancer survivors than in women with de novo breast cancer. This increased mortality reflects the burden of comorbidity and highlights the need for risk-reducing interventions.

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