Chinchillas were given either a single injection of the diuretic bumetanide (18 mg/kg body weight) or saline-sodium hydroxide and sacrificed at 10 min, 1 hr and 24 hr after the injection. Slight stria edema was present at 10 min, marked edema at 1 hr and no edema 24 h after bumetanide. The edema began in the first cochlear turn at 10 min and spread to the second turn by 1 hr. Along with edema, marginal cell bulging, potential capillary constriction and the formation of marginal cell membranous structures occurred after bumetanide treatment.
Bibliographical noteFunding Information:
This research was supported by NINCDS grants NS12125 and NS04615. The authors would like to thank Dr W. E. Scott of Hoffmann-LaRoche of Nutley, N.J. for supplying the bumetanide, Ms Pat Schachern for her excellent technical assistance and Dr Marilyn Carroll for her critical review of the manuscript and drawing of the graph.