Morphine tolerance, physical dependence, and synthesis of brain 5-hydroxytryptamine

E. Leong Way, Horace H. Loh, Fu Hsiung Shen

Research output: Contribution to journalArticle

194 Scopus citations

Abstract

Tolerance and physical dependence development to morphine in mice can be prevented by concomitant administration of cycloheximide. The fact that the rate of synthesis of brain 5-hydroxytryptamine (5HT) increases with tolerance to morphine suggests that the protein involved may be associated with 5HT synthesis. Inhibition of this synthesis with p-chlorophenylalanine markedly decreases tolerance and physical dependence development to morphine.

Original languageEnglish (US)
Pages (from-to)1290-1292
Number of pages3
JournalScience
Volume162
Issue number3859
DOIs
StatePublished - Jan 1 1968

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