Morphine modulates γδ lymphocytes cytolytic activity following BCG vaccination

Michael R Olin; Keum Hwa Choi; Jinhee Lee; Phillip K. Peterson; Thomas W Molitor

doi:10.1016/j.bbi.2006.06.003

Morphine modulates γδ lymphocytes cytolytic activity following BCG vaccination

Michael R Olin
, Keum Hwa Choi
, Jinhee Lee
, Phillip K. Peterson
, Thomas W Molitor

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Chronic opioid administration modulates lymphocytes' functional capabilities increasing susceptibility to infectious diseases. Bacille-Calmette-Guérin (BCG) vaccination initiates a non-specific and specific cell-mediated immunity orchestrated by T lymphocytes including γδ T lymphocytes. γδ T lymphocytes increase in natural killer and antigen-directed cytolytic response following BCG vaccination. The objective of this study was to determine morphine effects on γδ T lymphocytes' cytolytic activity. Pigs were chronically administered morphine and subsequently vaccinated with Mycobacterium bovis BCG. By administering morphine prior to BCG vaccination, natural killer response was significantly suppressed (p = .034). Furthermore, innate cytolytic response against M. bovis-infected monocytes (p = .002) as well as antigen specific cytolytic functions (p = .04) were significantly altered due to morphine administration. It was concluded that administering morphine prior to BCG vaccination significantly altered γδ T lymphocyte cytolytic responses.

Original language	English (US)
Pages (from-to)	195-201
Number of pages	7
Journal	Brain, Behavior, and Immunity
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.bbi.2006.06.003
State	Published - Feb 2007

Bibliographical note

Funding Information:
Special thanks to Dr. Jack Risdahl for the donation of the animals used in this study. Michael Olin was supported by National Institute of Health, National Research Service Award T32 DA07097 from the National Institute on Drug Abuse. This research was funded by the NIH (5R01DA08496).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cytolytic activity
Mycobacteria bovis BCG
NK activity
Opioids
γδ T lymphocyte

Publisher link

10.1016/j.bbi.2006.06.003

Find It

Find It at U of M Libraries

Cite this

@article{7d36aa202dcc48029723d3bffeadc6e5,

title = "Morphine modulates γδ lymphocytes cytolytic activity following BCG vaccination",

abstract = "Chronic opioid administration modulates lymphocytes' functional capabilities increasing susceptibility to infectious diseases. Bacille-Calmette-Gu{\'e}rin (BCG) vaccination initiates a non-specific and specific cell-mediated immunity orchestrated by T lymphocytes including γδ T lymphocytes. γδ T lymphocytes increase in natural killer and antigen-directed cytolytic response following BCG vaccination. The objective of this study was to determine morphine effects on γδ T lymphocytes' cytolytic activity. Pigs were chronically administered morphine and subsequently vaccinated with Mycobacterium bovis BCG. By administering morphine prior to BCG vaccination, natural killer response was significantly suppressed (p = .034). Furthermore, innate cytolytic response against M. bovis-infected monocytes (p = .002) as well as antigen specific cytolytic functions (p = .04) were significantly altered due to morphine administration. It was concluded that administering morphine prior to BCG vaccination significantly altered γδ T lymphocyte cytolytic responses.",

keywords = "Cytolytic activity, Mycobacteria bovis BCG, NK activity, Opioids, γδ T lymphocyte",

author = "Olin, \{Michael R\} and Choi, \{Keum Hwa\} and Jinhee Lee and Peterson, \{Phillip K.\} and Molitor, \{Thomas W\}",

note = "Funding Information: Special thanks to Dr. Jack Risdahl for the donation of the animals used in this study. Michael Olin was supported by National Institute of Health, National Research Service Award T32 DA07097 from the National Institute on Drug Abuse. This research was funded by the NIH (5R01DA08496).",

year = "2007",

month = feb,

doi = "10.1016/j.bbi.2006.06.003",

language = "English (US)",

volume = "21",

pages = "195--201",

journal = "Brain, Behavior, and Immunity",

issn = "0889-1591",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Morphine modulates γδ lymphocytes cytolytic activity following BCG vaccination

AU - Olin, Michael R

AU - Choi, Keum Hwa

AU - Lee, Jinhee

AU - Peterson, Phillip K.

AU - Molitor, Thomas W

N1 - Funding Information: Special thanks to Dr. Jack Risdahl for the donation of the animals used in this study. Michael Olin was supported by National Institute of Health, National Research Service Award T32 DA07097 from the National Institute on Drug Abuse. This research was funded by the NIH (5R01DA08496).

PY - 2007/2

Y1 - 2007/2

N2 - Chronic opioid administration modulates lymphocytes' functional capabilities increasing susceptibility to infectious diseases. Bacille-Calmette-Guérin (BCG) vaccination initiates a non-specific and specific cell-mediated immunity orchestrated by T lymphocytes including γδ T lymphocytes. γδ T lymphocytes increase in natural killer and antigen-directed cytolytic response following BCG vaccination. The objective of this study was to determine morphine effects on γδ T lymphocytes' cytolytic activity. Pigs were chronically administered morphine and subsequently vaccinated with Mycobacterium bovis BCG. By administering morphine prior to BCG vaccination, natural killer response was significantly suppressed (p = .034). Furthermore, innate cytolytic response against M. bovis-infected monocytes (p = .002) as well as antigen specific cytolytic functions (p = .04) were significantly altered due to morphine administration. It was concluded that administering morphine prior to BCG vaccination significantly altered γδ T lymphocyte cytolytic responses.

AB - Chronic opioid administration modulates lymphocytes' functional capabilities increasing susceptibility to infectious diseases. Bacille-Calmette-Guérin (BCG) vaccination initiates a non-specific and specific cell-mediated immunity orchestrated by T lymphocytes including γδ T lymphocytes. γδ T lymphocytes increase in natural killer and antigen-directed cytolytic response following BCG vaccination. The objective of this study was to determine morphine effects on γδ T lymphocytes' cytolytic activity. Pigs were chronically administered morphine and subsequently vaccinated with Mycobacterium bovis BCG. By administering morphine prior to BCG vaccination, natural killer response was significantly suppressed (p = .034). Furthermore, innate cytolytic response against M. bovis-infected monocytes (p = .002) as well as antigen specific cytolytic functions (p = .04) were significantly altered due to morphine administration. It was concluded that administering morphine prior to BCG vaccination significantly altered γδ T lymphocyte cytolytic responses.

KW - Cytolytic activity

KW - Mycobacteria bovis BCG

KW - NK activity

KW - Opioids

KW - γδ T lymphocyte

UR - https://www.scopus.com/pages/publications/33845932544

UR - https://www.scopus.com/pages/publications/33845932544#tab=citedBy

U2 - 10.1016/j.bbi.2006.06.003

DO - 10.1016/j.bbi.2006.06.003

M3 - Article

C2 - 16870392

AN - SCOPUS:33845932544

SN - 0889-1591

VL - 21

SP - 195

EP - 201

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

IS - 2

ER -

Morphine modulates γδ lymphocytes cytolytic activity following BCG vaccination

Abstract

Bibliographical note

UN SDGs

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this