Morphine analgesia potentiated but tolerance not affected by active immunization against cholecystokinin

Patricia L. Faris, Carol L. McLaughlin, Clifton A. Baile, John W. Olney, Barry R. Komisaruk

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Administration of cholecystokinin was recently found to attenuate opiate analgesia. In the present study, the role of endogenous cholecystokinin in opiate analgesia was examined. Endogenously released cholecystokinin was sequestered by antibodies to cholecystokinin developed in response to an active immunization procedure. Morphine analgesia was potentiated and prolonged in rats immunized against cholecystokinin. The rate of development of morphine tolerance, however, was not affected by the antibodies. Endogenous cholecystokinin appears to function as a short-term modulator of opiate action.

Original languageEnglish (US)
Pages (from-to)1215-1217
Number of pages3
JournalScience
Volume226
Issue number4679
DOIs
StatePublished - 1984

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