More than a FAD: The invivo effects of disease-linked presenilin-1 mutations

Kathleen R. Zahs; Karen H. Ashe

doi:10.1016/j.neuron.2015.02.021

More than a FAD: The invivo effects of disease-linked presenilin-1 mutations

Kathleen R. Zahs, Karen H. Ashe

Neurology

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

Mutations in presenilins are linked to familial autosomal dominant Alzheimer's disease. In this issue of Neuron, Xia etal. (2015) show that a disease-linked mutation leads to loss of γ-secretase function, cognitive decline, and neurodegeneration when knocked into the mouse genome. Mutations in presenilins are linked to familial autosomal dominant Alzheimer's disease. In this issue of Neuron, Xia etal. (2015) show that a disease-linked mutation leads to loss of γ-secretase function, cognitive decline, and neurodegeneration when knocked into the mouse genome.

Original language	English (US)
Pages (from-to)	893-895
Number of pages	3
Journal	Neuron
Volume	85
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2015.02.021
State	Published - Mar 4 2015

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abstract = "Mutations in presenilins are linked to familial autosomal dominant Alzheimer's disease. In this issue of Neuron, Xia etal. (2015) show that a disease-linked mutation leads to loss of γ-secretase function, cognitive decline, and neurodegeneration when knocked into the mouse genome. Mutations in presenilins are linked to familial autosomal dominant Alzheimer's disease. In this issue of Neuron, Xia etal. (2015) show that a disease-linked mutation leads to loss of γ-secretase function, cognitive decline, and neurodegeneration when knocked into the mouse genome.",

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More than a FAD: The invivo effects of disease-linked presenilin-1 mutations

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