More than a FAD: The invivo effects of disease-linked presenilin-1 mutations

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Abstract

Mutations in presenilins are linked to familial autosomal dominant Alzheimer's disease. In this issue of Neuron, Xia etal. (2015) show that a disease-linked mutation leads to loss of γ-secretase function, cognitive decline, and neurodegeneration when knocked into the mouse genome. Mutations in presenilins are linked to familial autosomal dominant Alzheimer's disease. In this issue of Neuron, Xia etal. (2015) show that a disease-linked mutation leads to loss of γ-secretase function, cognitive decline, and neurodegeneration when knocked into the mouse genome.

Original languageEnglish (US)
Pages (from-to)893-895
Number of pages3
JournalNeuron
Volume85
Issue number5
DOIs
StatePublished - Mar 4 2015

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