More on the need for circadian, circaseptan and circannual optimization of cyclosporine therapy

T. Liu, M. Cavallini, F. Halberg, Germaine G Cornelissen-Guillaume, J. Field, D. E.R. Sutherland

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Cyclosporine chronotherapy of pancreas-allotransplanted rats revealed, beyond a circadian stage-dependence of equal daily doses, further gain in graft function from doses varying from day to day with an about 7-day periodicity, the first highest dose being given on the 3rd or 5th day after surgery.

Original languageEnglish (US)
Pages (from-to)20-22
Number of pages3
JournalExperientia
Volume42
Issue number1
DOIs
StatePublished - Jan 1986

Keywords

  • Pancreatic allograft
  • circadian
  • circannual
  • circaseptan
  • cyclosporine chronotherapy

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