Monte Carlo Optimization of Liver Machine Perfusion Temperature Policies

Angelo Lucia; Korkut Uygun

doi:10.1007/978-3-031-25891-6_22

Monte Carlo Optimization of Liver Machine Perfusion Temperature Policies

Angelo Lucia, Korkut Uygun

Advanced Technologies for Preservation of Biological Systems

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In this work, a constrained multi-objective function formulation of liver machine perfusion (MP) based on widely accepted viability criteria and network metabolic efficiency is described. A novel Monte Carlo method is used to improve machine perfusion (MP) performance by finding optimal temperature policies for hypothermic machine perfusion (HMP), mid-thermic machine perfusion (MMP), and subnormothermic machine perfusion (SNMP). It is shown that the multi-objective function formulation can exhibit multiple maxima, that greedy optimization can get stuck at a local optimum, and that Monte Carlo optimization finds the best temperature policy in each case.

Original language	English (US)
Title of host publication	Machine Learning, Optimization, and Data Science - 8th International Workshop, LOD 2022, Revised Selected Papers
Editors	Giuseppe Nicosia, Giovanni Giuffrida, Varun Ojha, Emanuele La Malfa, Gabriele La Malfa, Panos Pardalos, Giuseppe Di Fatta, Renato Umeton
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	296-303
Number of pages	8
ISBN (Print)	9783031258909
DOIs	https://doi.org/10.1007/978-3-031-25891-6_22
State	Published - 2023
Event	8th International Conference on Machine Learning, Optimization, and Data Science, LOD 2022, held in conjunction with the 2nd Advanced Course and Symposium on Artificial Intelligence and Neuroscience, ACAIN 2022 - Certosa di Pontignano, Italy Duration: Sep 18 2022 → Sep 22 2022

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	13811 LNCS
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	8th International Conference on Machine Learning, Optimization, and Data Science, LOD 2022, held in conjunction with the 2nd Advanced Course and Symposium on Artificial Intelligence and Neuroscience, ACAIN 2022
Country/Territory	Italy
City	Certosa di Pontignano
Period	9/18/22 → 9/22/22

Bibliographical note

Funding Information:
Acknowledgement. This material is partially based upon work supported by the National Science Foundation under Grant No. EEC 1941543. Support from the US National Institutes of Health (grants R01DK096075 and R01DK114506) and the Shriners Hospitals for Children is gratefully acknowledged.

Publisher Copyright:
© 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Keywords

Machine perfusion
Monte Carlo
Multi-objective optimization

Publisher link

10.1007/978-3-031-25891-6_22

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Cite this

Lucia, A., & Uygun, K. (2023). Monte Carlo Optimization of Liver Machine Perfusion Temperature Policies. In G. Nicosia, G. Giuffrida, V. Ojha, E. La Malfa, G. La Malfa, P. Pardalos, G. Di Fatta, & R. Umeton (Eds.), Machine Learning, Optimization, and Data Science - 8th International Workshop, LOD 2022, Revised Selected Papers (pp. 296-303). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 13811 LNCS). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-031-25891-6_22

Monte Carlo Optimization of Liver Machine Perfusion Temperature Policies. / Lucia, Angelo; Uygun, Korkut.
Machine Learning, Optimization, and Data Science - 8th International Workshop, LOD 2022, Revised Selected Papers. ed. / Giuseppe Nicosia; Giovanni Giuffrida; Varun Ojha; Emanuele La Malfa; Gabriele La Malfa; Panos Pardalos; Giuseppe Di Fatta; Renato Umeton. Springer Science and Business Media Deutschland GmbH, 2023. p. 296-303 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 13811 LNCS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Lucia, A & Uygun, K 2023, Monte Carlo Optimization of Liver Machine Perfusion Temperature Policies. in G Nicosia, G Giuffrida, V Ojha, E La Malfa, G La Malfa, P Pardalos, G Di Fatta & R Umeton (eds), Machine Learning, Optimization, and Data Science - 8th International Workshop, LOD 2022, Revised Selected Papers. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 13811 LNCS, Springer Science and Business Media Deutschland GmbH, pp. 296-303, 8th International Conference on Machine Learning, Optimization, and Data Science, LOD 2022, held in conjunction with the 2nd Advanced Course and Symposium on Artificial Intelligence and Neuroscience, ACAIN 2022, Certosa di Pontignano, Italy, 9/18/22. https://doi.org/10.1007/978-3-031-25891-6_22

Lucia A, Uygun K. Monte Carlo Optimization of Liver Machine Perfusion Temperature Policies. In Nicosia G, Giuffrida G, Ojha V, La Malfa E, La Malfa G, Pardalos P, Di Fatta G, Umeton R, editors, Machine Learning, Optimization, and Data Science - 8th International Workshop, LOD 2022, Revised Selected Papers. Springer Science and Business Media Deutschland GmbH. 2023. p. 296-303. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/978-3-031-25891-6_22

Lucia, Angelo ; Uygun, Korkut. / Monte Carlo Optimization of Liver Machine Perfusion Temperature Policies. Machine Learning, Optimization, and Data Science - 8th International Workshop, LOD 2022, Revised Selected Papers. editor / Giuseppe Nicosia ; Giovanni Giuffrida ; Varun Ojha ; Emanuele La Malfa ; Gabriele La Malfa ; Panos Pardalos ; Giuseppe Di Fatta ; Renato Umeton. Springer Science and Business Media Deutschland GmbH, 2023. pp. 296-303 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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Monte Carlo Optimization of Liver Machine Perfusion Temperature Policies

Abstract

Publication series

Conference

Bibliographical note

Keywords

Publisher link

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Other files and links

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ATP-Bio: NSF Engineering Research Center for Advanced Technologies for the Preservation of Biological Systems (ATP-Bio)

Cite this

Monte Carlo Optimization of Liver Machine Perfusion Temperature Policies

Abstract

Publication series

Conference

Bibliographical note

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Projects

ATP-Bio: NSF Engineering Research Center for Advanced Technologies for the Preservation of Biological Systems (ATP-Bio)

Cite this