Monofunctional group-modified gold nanoparticles from solid phase synthesis approach: Solid support and experimental condition effect

James G. Worden, Qiu Dai, Andrew W. Shaffer, Qun Huo

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

We herein report a systematic study of solid-phase place exchange reactions for the synthesis of gold nanoparticles with a single surface functional group. This approach is based on a "catch and release" mechanism to control the number of functional groups attached to the nanoparticle surface. Bifunctional thiol ligands with a carboxylic end group were first immobilized on a solid polymer support in a controlled density. The density was low enough that neighboring thiol ligands were far apart from each other. When the modified polymer support was incubated in a butanethiol-protected nanoparticle solution, a one-to-one place exchange reaction took place between the polymer-bound thiol ligands and the nanoparticles. After cleaving off from the solid support, nanoparticles with a single carboxylic group were obtained as the major product. By varying the solid supports and reaction conditions, we succeeded to obtain monofunctional gold nanoparticles with enhanced yield and high purity.

Original languageEnglish (US)
Pages (from-to)3746-3755
Number of pages10
JournalChemistry of Materials
Volume16
Issue number19
DOIs
StatePublished - Sep 21 2004

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