Abstract
The blood-brain barrier (BBB) is a dynamic structure that maintains the homeostasis of the brain and thus proper neurological functions. BBB compromise has been found in many pathological conditions, including neuroinflammation. Monocyte chemoattractant protein-1 (MCP1), a chemokine that is transiently and significantly up-regulated during inflammation, is able to disrupt the integrity of BBB and modulate the progression of various diseases, including excitotoxic injury and hemorrhage. In this review, we first introduce the biochemistry and biology of MCP1, and then summarize the effects of MCP1 on BBB integrity as well as individual BBB components.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 683-697 |
| Number of pages | 15 |
| Journal | Cellular and Molecular Life Sciences |
| Volume | 71 |
| Issue number | 4 |
| DOIs | |
| State | Published - Feb 2014 |
| Externally published | Yes |
Bibliographical note
Funding Information:We thank members of the Tsirka laboratory for discussions. This work was supported by NIH R01NS42168 (SET) and Sigma Xi Grant-in-Aid of Research (YY).
Keywords
- Astrocytes
- BBB
- BM
- BMECs
- MCP1
- Microglia
- Neurons
- Pericytes