Monocyte chemoattractant protein-1 and the blood-brain barrier

Yao Yao, Stella E. Tsirka

Research output: Contribution to journalReview article

69 Citations (Scopus)

Abstract

The blood-brain barrier (BBB) is a dynamic structure that maintains the homeostasis of the brain and thus proper neurological functions. BBB compromise has been found in many pathological conditions, including neuroinflammation. Monocyte chemoattractant protein-1 (MCP1), a chemokine that is transiently and significantly up-regulated during inflammation, is able to disrupt the integrity of BBB and modulate the progression of various diseases, including excitotoxic injury and hemorrhage. In this review, we first introduce the biochemistry and biology of MCP1, and then summarize the effects of MCP1 on BBB integrity as well as individual BBB components.

Original languageEnglish (US)
Pages (from-to)683-697
Number of pages15
JournalCellular and Molecular Life Sciences
Volume71
Issue number4
DOIs
StatePublished - Feb 1 2014

Fingerprint

Chemokine CCL2
Blood-Brain Barrier
Chemokines
Biochemistry
Disease Progression
Homeostasis
Hemorrhage
Inflammation
Wounds and Injuries
Brain

Keywords

  • Astrocytes
  • BBB
  • BM
  • BMECs
  • MCP1
  • Microglia
  • Neurons
  • Pericytes

Cite this

Monocyte chemoattractant protein-1 and the blood-brain barrier. / Yao, Yao; Tsirka, Stella E.

In: Cellular and Molecular Life Sciences, Vol. 71, No. 4, 01.02.2014, p. 683-697.

Research output: Contribution to journalReview article

Yao, Yao ; Tsirka, Stella E. / Monocyte chemoattractant protein-1 and the blood-brain barrier. In: Cellular and Molecular Life Sciences. 2014 ; Vol. 71, No. 4. pp. 683-697.
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