Monocyte chemoattractant protein-1 and the blood-brain barrier

Yao Yao, Stella E. Tsirka

Research output: Contribution to journalReview articlepeer-review

105 Scopus citations


The blood-brain barrier (BBB) is a dynamic structure that maintains the homeostasis of the brain and thus proper neurological functions. BBB compromise has been found in many pathological conditions, including neuroinflammation. Monocyte chemoattractant protein-1 (MCP1), a chemokine that is transiently and significantly up-regulated during inflammation, is able to disrupt the integrity of BBB and modulate the progression of various diseases, including excitotoxic injury and hemorrhage. In this review, we first introduce the biochemistry and biology of MCP1, and then summarize the effects of MCP1 on BBB integrity as well as individual BBB components.

Original languageEnglish (US)
Pages (from-to)683-697
Number of pages15
JournalCellular and Molecular Life Sciences
Issue number4
StatePublished - Feb 2014
Externally publishedYes

Bibliographical note

Funding Information:
We thank members of the Tsirka laboratory for discussions. This work was supported by NIH R01NS42168 (SET) and Sigma Xi Grant-in-Aid of Research (YY).


  • Astrocytes
  • BBB
  • BM
  • BMECs
  • MCP1
  • Microglia
  • Neurons
  • Pericytes


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