Abstract
Two dogs, an 8.5-year-old intact male Golden Retriever and a 10-year-old spayed female English Springer Spaniel, each with varied clinical histories, were referred to the Colorado State University Veterinary Teaching Hospital for evaluation of hypercalcemia and severe anemia, respectively. In each dog, serum total protein and globulin concentrations were within reference intervals. Cytologic examination of bone marrow aspirates from both dogs revealed moderate to marked numbers of atypical lymphoid cells with plasma cell features. Using serum immunofixation and serum immunoglobulin (Ig) quantification, a monoclonal Ig protein was identified. In conjunction with other clinicopathologic and molecular findings, IgA secretory neoplasms, B-cell lymphoma with plasmacytoid features and multiple myeloma (MM), were diagnosed. To our knowledge, these cases represent the first descriptions of IgA-secreting neoplasms in dogs that lacked hyperglobulinemia. In cases of suspected B-cell lymphoma or MM in dogs, serum proteins should be fully evaluated for the presence of a monoclonal Ig even in dogs that lack characteristic hyperproteinemia or hyperglobulinemia. This evaluation will aid in the diagnosis of secretory B-cell lymphoma or MM leading to appropriate clinical and therapeutic case management.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 447-453 |
| Number of pages | 7 |
| Journal | Veterinary Clinical Pathology |
| Volume | 39 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 2010 |
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Keywords
- B-cell lymphoma
- Immunofixation
- Immunoglobulin quantification
- Multiple myeloma
- Serum protein electrophoresis
Cite this
Monoclonal gammopathy without hyperglobulinemia in 2 dogs with IgA secretory neoplasms. / Seelig, Davis M.; Perry, James A.; Avery, Anne C.; Avery, Paul R.
In: Veterinary Clinical Pathology, Vol. 39, No. 4, 01.12.2010, p. 447-453.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Monoclonal gammopathy without hyperglobulinemia in 2 dogs with IgA secretory neoplasms
AU - Seelig, Davis M.
AU - Perry, James A.
AU - Avery, Anne C.
AU - Avery, Paul R.
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Two dogs, an 8.5-year-old intact male Golden Retriever and a 10-year-old spayed female English Springer Spaniel, each with varied clinical histories, were referred to the Colorado State University Veterinary Teaching Hospital for evaluation of hypercalcemia and severe anemia, respectively. In each dog, serum total protein and globulin concentrations were within reference intervals. Cytologic examination of bone marrow aspirates from both dogs revealed moderate to marked numbers of atypical lymphoid cells with plasma cell features. Using serum immunofixation and serum immunoglobulin (Ig) quantification, a monoclonal Ig protein was identified. In conjunction with other clinicopathologic and molecular findings, IgA secretory neoplasms, B-cell lymphoma with plasmacytoid features and multiple myeloma (MM), were diagnosed. To our knowledge, these cases represent the first descriptions of IgA-secreting neoplasms in dogs that lacked hyperglobulinemia. In cases of suspected B-cell lymphoma or MM in dogs, serum proteins should be fully evaluated for the presence of a monoclonal Ig even in dogs that lack characteristic hyperproteinemia or hyperglobulinemia. This evaluation will aid in the diagnosis of secretory B-cell lymphoma or MM leading to appropriate clinical and therapeutic case management.
AB - Two dogs, an 8.5-year-old intact male Golden Retriever and a 10-year-old spayed female English Springer Spaniel, each with varied clinical histories, were referred to the Colorado State University Veterinary Teaching Hospital for evaluation of hypercalcemia and severe anemia, respectively. In each dog, serum total protein and globulin concentrations were within reference intervals. Cytologic examination of bone marrow aspirates from both dogs revealed moderate to marked numbers of atypical lymphoid cells with plasma cell features. Using serum immunofixation and serum immunoglobulin (Ig) quantification, a monoclonal Ig protein was identified. In conjunction with other clinicopathologic and molecular findings, IgA secretory neoplasms, B-cell lymphoma with plasmacytoid features and multiple myeloma (MM), were diagnosed. To our knowledge, these cases represent the first descriptions of IgA-secreting neoplasms in dogs that lacked hyperglobulinemia. In cases of suspected B-cell lymphoma or MM in dogs, serum proteins should be fully evaluated for the presence of a monoclonal Ig even in dogs that lack characteristic hyperproteinemia or hyperglobulinemia. This evaluation will aid in the diagnosis of secretory B-cell lymphoma or MM leading to appropriate clinical and therapeutic case management.
KW - B-cell lymphoma
KW - Immunofixation
KW - Immunoglobulin quantification
KW - Multiple myeloma
KW - Serum protein electrophoresis
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UR - http://www.scopus.com/inward/citedby.url?scp=78649901490&partnerID=8YFLogxK
U2 - 10.1111/j.1939-165X.2010.00262.x
DO - 10.1111/j.1939-165X.2010.00262.x
M3 - Article
C2 - 20969607
AN - SCOPUS:78649901490
VL - 39
SP - 447
EP - 453
JO - Veterinary Clinical Pathology
JF - Veterinary Clinical Pathology
SN - 0275-6382
IS - 4
ER -