Monoclonal gammopathy in hereditary spherocytosis: A possible pathogenetic relation

A. I. Schafer, J. B. Miller, E. P. Lester, T. K. Bowers, Harry S Jacob

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Two cases of monoclonal gammopathy in patients with hereditary spherocytosis led us to consider the possible pathogenetic relation between these two disorders. Twelve adult patients with hereditary spherocytosis had significant hypergammaglobulinemia in comparison to normal subjects. Retrospective analysis of previous illness in 140 patients with multiple myeloma showed a significant association between IgA myeloma and previous gallbladder disease. We propose that the chronic reticuloendothelial stimulation due to extravascular hemolysis, possibly potentiated by the inflammation associated with cholelithiasis and cholecystitis, may foster neoplastic transformation of immunocytes in patients with hereditary spherocytosis, ultimately leading to the development of monoclonal gammopathy.

Original languageEnglish (US)
Pages (from-to)45-46
Number of pages2
JournalUnknown Journal
Issue number1
StatePublished - Jan 1 1978


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