Abstract
MCA (monocarboxylic acid) transporters are significant for their role in intermediary metabolism, pathology, and genetic diseases. They are also relevant to pharmacology because of their ability to transport carboxylated pharmaceuticals (drug delivery) and as targets of therapeutic agents. The mature mitochondrial pyruvate carrier (MPC)1 and MPC2 proteins each contain two transmembrane segments and are located in the inner mitochondrial membrane. The two proteins are believed to form a heterodimer and with other proteins form a 150kDa complex that carries pyruvate into the mitochondria. Based on sequence homologies, the SLC5 transporter gene family consists of 12 members and their related protein products. A major function of the sodium-dependent monocarboxylate transporters (SMCTs) is absorption of lactate from the renal ultrafiltrate as it passes through the kidney tubules. The family of mammalian MCTs is officially assigned the name SLC16, and there are 14 unique members designated SLC16A1 through SLC16A14.
| Original language | English (US) |
|---|---|
| Title of host publication | Drug Transporters |
| Subtitle of host publication | Molecular Characterization and Role in Drug Disposition: Second Edition |
| Publisher | Wiley-Blackwell |
| Pages | 91-106 |
| Number of pages | 16 |
| Volume | 9781118489932 |
| ISBN (Electronic) | 9781118705308 |
| ISBN (Print) | 9781118489932 |
| DOIs | |
| State | Published - Sep 2 2014 |
Bibliographical note
Publisher Copyright:© 2014 by John Wiley & Sons, Inc. All rights reserved.
Keywords
- Mitochondrial pyruvate carrier (MPC)
- Monocarboxylic acid (MCA) transporters
- SLC16 transporters
- SLC5 transporter
- Sodium-dependent monocarboxylate transporters (SMCTs)