Monocarboxylic Acid Transporters

Zejian Liu, Lester R Drewes

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

MCA (monocarboxylic acid) transporters are significant for their role in intermediary metabolism, pathology, and genetic diseases. They are also relevant to pharmacology because of their ability to transport carboxylated pharmaceuticals (drug delivery) and as targets of therapeutic agents. The mature mitochondrial pyruvate carrier (MPC)1 and MPC2 proteins each contain two transmembrane segments and are located in the inner mitochondrial membrane. The two proteins are believed to form a heterodimer and with other proteins form a 150kDa complex that carries pyruvate into the mitochondria. Based on sequence homologies, the SLC5 transporter gene family consists of 12 members and their related protein products. A major function of the sodium-dependent monocarboxylate transporters (SMCTs) is absorption of lactate from the renal ultrafiltrate as it passes through the kidney tubules. The family of mammalian MCTs is officially assigned the name SLC16, and there are 14 unique members designated SLC16A1 through SLC16A14.

Original languageEnglish (US)
Title of host publicationDrug Transporters
Subtitle of host publicationMolecular Characterization and Role in Drug Disposition: Second Edition
PublisherWiley-Blackwell
Pages91-106
Number of pages16
Volume9781118489932
ISBN (Electronic)9781118705308
ISBN (Print)9781118489932
DOIs
StatePublished - Sep 2 2014

Keywords

  • Mitochondrial pyruvate carrier (MPC)
  • Monocarboxylic acid (MCA) transporters
  • SLC16 transporters
  • SLC5 transporter
  • Sodium-dependent monocarboxylate transporters (SMCTs)

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  • Cite this

    Liu, Z., & Drewes, L. R. (2014). Monocarboxylic Acid Transporters. In Drug Transporters: Molecular Characterization and Role in Drug Disposition: Second Edition (Vol. 9781118489932, pp. 91-106). Wiley-Blackwell. https://doi.org/10.1002/9781118705308.ch6