Monitoring phase transformations in intact tablets of trehalose by FT-raman spectroscopy

Paroma Chakravarty, Sunny P. Bhardwaj, Leslie King, Raj Suryanarayanan

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The purpose of this study is to monitor phase transformations in intact trehalose tablets using FT-Raman spectroscopy. Tablets of trehalose dihydrate, amorphous trehalose (obtained by freeze-drying aqueous trehalose solutions), and anhydrous trehalose (β-trehalose) were prepared. The tablets were exposed to different conditions [11% and 0% RH (60°C); 75% RH (25°C)] and monitored periodically over 96 h using Raman spectroscopy. Within 96 h of storage, the following phase transformations were observed: (1) trehalose dihydrate → β-trehalose (11% RH, 60°C), (2) trehalose dihydrate → α-trehalose (0% RH, 60°C), (3) β-trehalose → trehalose dihydrate (75% RH, 25°C), and (4) amorphous trehalose → trehalose dihydrate (75% RH, 25°C). FT-Raman spectroscopy was a useful technique to identify the solid form and monitor multiple-phase transformations in intact trehalose tablets stored at different conditions.

Original languageEnglish (US)
Pages (from-to)1420-1426
Number of pages7
JournalAAPS PharmSciTech
Volume10
Issue number4
DOIs
StatePublished - Dec 1 2009

Keywords

  • Phase transformation
  • Raman spectroscopy
  • Tablet
  • Trehalose

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