Abstract
A 12-y-old, castrated male Pomeranian dog was presented because of mandibular lymph node (LN) enlargement. Physical examination and a complete blood count revealed generalized lymphadenopathy and moderate lymphocytosis. Fine-needle aspirate cytology revealed expansion of medium lymphocytes in the right mandibular LN and expansion of large lymphocytes in the left popliteal LN. Flow cytometry identified 2 aberrant lymphocyte populations in both LNs, namely a CD5+CD45− T-cell population, and a large CD21+ B-cell population. Flow cytometry of the peripheral blood revealed an identical population of aberrant CD45− T cells. The patient was diagnosed with concurrent T-zone lymphoma and leukemia, and B-cell lymphoma. Multi-agent chemotherapy was instituted, and serial clinical and flow cytometric analysis revealed complete remission of the neoplastic B cells, but persistence of the neoplastic T cells and persistent lymphadenopathy. This case affirms the diagnostic value of flow cytometry and reveals a unique limitation of the RECIST criteria.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1008-1012 |
| Number of pages | 5 |
| Journal | Journal of Veterinary Diagnostic Investigation |
| Volume | 33 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2021 |
Bibliographical note
Publisher Copyright:© 2021 The Author(s).
Keywords
- B-cell lymphoma
- RECIST criteria
- T-zone lymphoma/leukemia
- cytology
- dogs
- flow cytometry
- lymph node
