Monitoring for cardiovascular disease in survivors of childhood cancer: Report from the cardiovascular disease task force of the children's oncology group

Sadhna M. Shankar, Neyssa Marina, Melissa M. Hudson, David C. Hodgson, M. Jacob Adams, Wendy Landier, Smita Bhatia, Kathleen Meeske, Hui Chen Ming, Karen E. Kinahan, Julia Steinberger, David Rosenthal

Research output: Contribution to journalReview article

195 Scopus citations

Abstract

Curative therapy for childhood cancer has improved significantly in the last 2 decades such that, at present, ∼80% of all children with cancer are likely to survive ≥5 years after diagnosis. Prevention, early diagnosis, and treatment of long-term sequelae of therapy have become increasingly more significant as survival rates continue to improve. Cardiovascular disease is a well-recognized cause of increased late morbidity and mortality among survivors of childhood cancer. The Children's Oncology Group Late Effects Committee and Nursing Discipline and Patient Advocacy Committee have recently developed guidelines for follow-up of long-term survivors of pediatric cancer. A multidisciplinary task force critically reviewed the existing literature to evaluate the evidence for the cardiovascular screening recommended by the Children's Oncology Group guidelines. In this review we outline the clinical manifestations of late cardiovascular toxicities, suggest modalities and frequency of monitoring, and address some of the controversial and unresolved issues regarding cardiovascular disease in childhood cancer survivors.

Original languageEnglish (US)
Pages (from-to)e387-e396
JournalPediatrics
Volume121
Issue number2
DOIs
StatePublished - Feb 1 2008

Keywords

  • Anthracyclines
  • Cancer
  • Cardiomyopathy
  • Radiation therapy
  • Survivor

Fingerprint Dive into the research topics of 'Monitoring for cardiovascular disease in survivors of childhood cancer: Report from the cardiovascular disease task force of the children's oncology group'. Together they form a unique fingerprint.

  • Cite this

    Shankar, S. M., Marina, N., Hudson, M. M., Hodgson, D. C., Adams, M. J., Landier, W., Bhatia, S., Meeske, K., Ming, H. C., Kinahan, K. E., Steinberger, J., & Rosenthal, D. (2008). Monitoring for cardiovascular disease in survivors of childhood cancer: Report from the cardiovascular disease task force of the children's oncology group. Pediatrics, 121(2), e387-e396. https://doi.org/10.1542/peds.2007-0575