Abstract
In this article, spectral domain optical coherence tomography is used to measure the hemodynamic response induced by optogenetic stimulation in the somatosensory cortex of transgenic mice. By analyzing the 3-D angiograms and Doppler measurements produced by coherence tomography, we observed significant increase in blood flow as a result of increased vessel diameter and blood velocity following optical stimulation of cortical neurons. Such distinct responses were not observed in control experiments where the brain of wild-type mice were exposed to the same light pulses.
| Original language | English (US) |
|---|---|
| Article number | 6942241 |
| Pages (from-to) | 766-773 |
| Number of pages | 8 |
| Journal | IEEE Transactions on Biomedical Engineering |
| Volume | 62 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2015 |
Bibliographical note
Publisher Copyright:© 1964-2012 IEEE.
Keywords
- Functional monitoring and imaging
- Laser Doppler velocimetry.
- Medical and biological imaging
- Optical coherence tomography
- Optogenetics
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