Monitoring cerebral hemodynamics following optogenetic stimulation via optical coherence tomography

Farid Atry, Seth Frye, Thomas J. Richner, Sarah K. Brodnick, Alana Soehartono, Justin Williams, Ramin Pashaie

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

In this article, spectral domain optical coherence tomography is used to measure the hemodynamic response induced by optogenetic stimulation in the somatosensory cortex of transgenic mice. By analyzing the 3-D angiograms and Doppler measurements produced by coherence tomography, we observed significant increase in blood flow as a result of increased vessel diameter and blood velocity following optical stimulation of cortical neurons. Such distinct responses were not observed in control experiments where the brain of wild-type mice were exposed to the same light pulses.

Original languageEnglish (US)
Article number6942241
Pages (from-to)766-773
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Volume62
Issue number2
DOIs
StatePublished - Feb 1 2015

Bibliographical note

Publisher Copyright:
© 1964-2012 IEEE.

Keywords

  • Functional monitoring and imaging
  • Laser Doppler velocimetry.
  • Medical and biological imaging
  • Optical coherence tomography
  • Optogenetics

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