Monitoring cerebral hemodynamics following optogenetic stimulation via optical coherence tomography

Farid Atry; Seth Frye; Thomas J. Richner; Sarah K. Brodnick; Alana Soehartono; Justin Williams; Ramin Pashaie

doi:10.1109/TBME.2014.2364816

Monitoring cerebral hemodynamics following optogenetic stimulation via optical coherence tomography

Farid Atry, Seth Frye, Thomas J. Richner, Sarah K. Brodnick, Alana Soehartono, Justin Williams, Ramin Pashaie

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

In this article, spectral domain optical coherence tomography is used to measure the hemodynamic response induced by optogenetic stimulation in the somatosensory cortex of transgenic mice. By analyzing the 3-D angiograms and Doppler measurements produced by coherence tomography, we observed significant increase in blood flow as a result of increased vessel diameter and blood velocity following optical stimulation of cortical neurons. Such distinct responses were not observed in control experiments where the brain of wild-type mice were exposed to the same light pulses.

Original language	English (US)
Article number	6942241
Pages (from-to)	766-773
Number of pages	8
Journal	IEEE Transactions on Biomedical Engineering
Volume	62
Issue number	2
DOIs	https://doi.org/10.1109/TBME.2014.2364816
State	Published - Feb 1 2015

Bibliographical note

Publisher Copyright:
© 1964-2012 IEEE.

Keywords

Functional monitoring and imaging
Laser Doppler velocimetry.
Medical and biological imaging
Optical coherence tomography
Optogenetics

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10.1109/TBME.2014.2364816

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abstract = "In this article, spectral domain optical coherence tomography is used to measure the hemodynamic response induced by optogenetic stimulation in the somatosensory cortex of transgenic mice. By analyzing the 3-D angiograms and Doppler measurements produced by coherence tomography, we observed significant increase in blood flow as a result of increased vessel diameter and blood velocity following optical stimulation of cortical neurons. Such distinct responses were not observed in control experiments where the brain of wild-type mice were exposed to the same light pulses.",

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AU - Soehartono, Alana

AU - Williams, Justin

AU - Pashaie, Ramin

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Monitoring cerebral hemodynamics following optogenetic stimulation via optical coherence tomography

Abstract

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