Abstract
Maximal expression of the interleukin-2 gene in T cells depends on biochemical signals in addition to those transduced by the T cell antigen receptor. Recent work indicates that the T-cell specific molecule CD28 transduces a'costimulatory' signal when it binds its ligand, the B7 molecule, on the surface of an antigen-presenting cell. Results from experiments performed during the past year have raised the exciting possibility that immune responses can be either inhibited or augmented by manipulation of the CD28-B7 interaction.
Original language | English (US) |
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Pages (from-to) | 361-367 |
Number of pages | 7 |
Journal | Current Opinion in Immunology |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1993 |