Molecules involved in T-cell costimulation

Marc Jenkins, Julia G. Johnson

Research output: Contribution to journalArticlepeer-review

222 Scopus citations


Maximal expression of the interleukin-2 gene in T cells depends on biochemical signals in addition to those transduced by the T cell antigen receptor. Recent work indicates that the T-cell specific molecule CD28 transduces a'costimulatory' signal when it binds its ligand, the B7 molecule, on the surface of an antigen-presenting cell. Results from experiments performed during the past year have raised the exciting possibility that immune responses can be either inhibited or augmented by manipulation of the CD28-B7 interaction.

Original languageEnglish (US)
Pages (from-to)361-367
Number of pages7
JournalCurrent Opinion in Immunology
Issue number3
StatePublished - Jun 1993

Bibliographical note

Copyright 2014 Elsevier B.V., All rights reserved.


Dive into the research topics of 'Molecules involved in T-cell costimulation'. Together they form a unique fingerprint.

Cite this