Molecular targets of phytochemicals for cancer prevention

Ki Won Lee, Ann M. Bode, Zigang Dong

Research output: Contribution to journalReview articlepeer-review

389 Scopus citations

Abstract

Although successful for a limited number of tumour types, the efficacy of cancer therapies, especially for late-stage disease, remains poor overall. Many have argued that this could be avoided by focusing on cancer prevention, which has now entered the arena of targeted therapies. During the process of identifying preventive agents, dietary phytochemicals, which are thought to be safe for human use, have emerged as modulators of key cellular signalling pathways. The task now is to understand how these chemicals perturb these pathways by modelling their interactions with their target proteins.

Original languageEnglish (US)
Pages (from-to)211-218
Number of pages8
JournalNature Reviews Cancer
Volume11
Issue number3
DOIs
StatePublished - Mar 2011

Bibliographical note

Funding Information:
This article was supported by grants from the US National Institutes of Health CA077646, CA111536, CA111536, CA120388, ES016548 and R37CA081064, The Hormel Foundation, and the Leap Research Program (No. 2010-0029,233) and the World Class Institute Program founded by the Korea Research Foundation, Ministry of Education, Science and Technology, Republic of Korea.

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