Molecular Targets of Coffee Phytochemicals Caffeic Acid and Chlorogenic Acid in Chemoprevention

Ann M. Bode, Zigang Dong

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Even though the health benefits and risks of coffee consumption have been debated for decades, epidemiological and animal studies are contradictory. Coffee includes a complex mixture of compounds, including various highly active phenols. Carcinogenesis is a complicated process involving hundreds of genes and gene products that regulate innumerable cellular functions. An emerging opinion is that cancer might be prevented with small molecules that target specific or multiple cancer genes or signaling proteins. Promising small molecule inhibitors include dietary factors-hence the interest in coffee and its role in chemoprevention. However, developing dietary factors or phytochemicals as anticancer agents is based on discovering specific molecular targets. We have shown that phytochemicals with defined mechanisms of action based on molecular target identification can be linked to successful drug discovery. This review chapter focuses on the anticancer effects and molecular targets of coffee, especially the caffeoylquinic acids and their phenolic degradation products.

Original languageEnglish (US)
Title of host publicationCoffee in Health and Disease Prevention
PublisherElsevier Inc.
Pages673-680
Number of pages8
ISBN (Electronic)9780124167162
ISBN (Print)9780124095175
DOIs
StatePublished - Jan 1 2015

Keywords

  • Anticancer agent
  • Molecular modeling
  • Phytochemical
  • Small molecule inhibitor
  • Virtual screening

Fingerprint

Dive into the research topics of 'Molecular Targets of Coffee Phytochemicals Caffeic Acid and Chlorogenic Acid in Chemoprevention'. Together they form a unique fingerprint.

Cite this