Molecular simulation of dynorphin A-(1-10) binding to extracellular loop 2 of the κ-opiod receptor. A model for receptor activation

Keyphrases

• Molecular Simulation 100%
• Opiod Receptors 100%
• Receptor Activation 100%
• Dynorphin A 100%
• Extracellular Loop 2 100%
• Opioids 33%
• Opioid Receptors 33%
• Helix 33%
• Aromatics 16%
• Site-directed mutagenesis 16%
• Opioid Ligands 16%
• Dynorphin 16%
• Transmembrane Domain 16%
• Amphiphilic 16%
• Binding Mode 16%
• Tyramine 16%
• Transmembrane Helix 16%
• Secondary Structure Prediction 16%
• N-terminal Region 16%
• Hydrophobic Residues 16%
• Chimera 16%
• Ligand-binding Domain 16%
• Extracellular Loop 16%
• Loop Region 16%
• Homology Modeling 16%
• Sigma-1 Receptor 16%
• Transmembrane Region 16%
• Helix-helix Interaction 16%
• Helical Motif 16%
• Ligand Complexes 16%
• Structure Prediction Methods 16%

Neuroscience

• Dynorphin A 100%
• Receptor 100%
• Tyramine 14%
• Amino Terminal Sequence 14%
• Dynorphin 14%
• Protein Secondary Structure 14%
• Site-Directed Mutagenesis 14%

Biochemistry, Genetics and Molecular Biology

• Dynorphin A 100%
• Opioid Receptor 33%
• Transmembrane Domain 16%
• Protein Secondary Structure 16%
• N-Terminus 16%
• Binding Domain 16%
• Homology Modeling 16%
• Site-Directed Mutagenesis 16%
• Dynorphin 16%
• Tyramine 16%