Developmental and regenerative mechanisms are directed by stem cell populations. Skeletal muscle is a dynamic tissue that is capable of adapting to stress and severe injury due to a resident somatic stem cell population. In response to a severe injury that destroys upward of 90% of the tissue, skeletal muscle efficiently and reproducibly regenerates damaged tissue and restores the cellular architecture within a 2-wk period. Recent studies have localized and examined the molecular regulation of skeletal muscle stem cell populations using emerging molecular biological technologies. These studies enhance the understanding of the regulatory mechanisms that direct the somatic stem cell populations and the role they play in development and regeneration. Furthermore, these basic science studies will serve as a platform for future therapies directed toward patients with myopathic diseases.
Bibliographical noteFunding Information:
The authors acknowledge the contributions of Dr. Robert Hammer, Dr. Annette Meeson, Teresa Gallardo, and Sean Goetsch. Funding support was obtained from the National Institutes of Health (AR47850), the Muscular Dystrophy Association, the Donald W. Reynolds Foundation, and the Gail Griffiths Hill Foundation.
- Array analysis
- Muscle stem cells
- SP cells
- Satellite cells