Molecular requirements for T cell activation by the staphylococcal toxic shock syndrome toxin-1

Steven D. Norton, Patrick M. Schlievert, Richard P. Novick, Marc Jenkins

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The activation of Ag-specific, Ia molecule-restricted, TCR Vβ3+ T cell clones by staphylococcal toxic shock syndrome toxin-1 (TSST-1), was investigated. The results show that although Ag- and TSST-1-induced activation of T cell clones both require TCR expression and similar biologic activation signals, the Ia molecule requirement for TSST-1 recognition was much less stringent than that observed for antigenic peptide recognition. In addition, T cell clones recognized TSST-1 without processing by APC. These results suggest that the ablity of TSST-1 to polyclonally activate T cells is dependent on TCR recognition of the intact toxin molecule bound to a nonpolymorphic region(s) of the Ia molecule resulting in the same activation events induced by Ag recognition.

Original languageEnglish (US)
Pages (from-to)2089-2095
Number of pages7
JournalJournal of Immunology
Volume144
Issue number6
StatePublished - 1990

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