Molecular pathways in malignant pleural mesothelioma

Bryan A. Whitson, Robert A Kratzke

Research output: Contribution to journalShort survey

33 Scopus citations

Abstract

Malignant pleural mesothelioma, although uncommon, is highly lethal. There is a high correlation between associated environmental exposure factors, carcinogens, and its development. Carcinogenesis is also mediated by genetic defects that result in loss of tumor suppressors or over expression of proto-oncogenes. Factors such as the loss of CDK inhibition function, IGF stimulatory pathways, p14ARF, p15INK4b, p16INK4a, p21, and p53 loss or mutation, VEGF and COX over expression are discussed. Correlations to potential therapeutic modalities are made.

Original languageEnglish (US)
Pages (from-to)183-189
Number of pages7
JournalCancer Letters
Volume239
Issue number2
DOIs
StatePublished - Aug 8 2006

Keywords

  • CDK inhibitor
  • IGF
  • Mesothelioma

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